Annals of Biomedical Engineering

, Volume 35, Issue 12, pp 2050–2064

Influence of Ventricular Pressure Drop on Mitral Annulus Dynamics Through the Process of Vortex Ring Formation

Article

DOI: 10.1007/s10439-007-9382-y

Cite this article as:
Kheradvar, A. & Gharib, M. Ann Biomed Eng (2007) 35: 2050. doi:10.1007/s10439-007-9382-y

Abstract

Several studies have suggested that the mitral annulus displacement and velocity in early diastole can be used as indicators of diastolic performance. The peak velocity of the mitral annulus away from the LV apex during early diastole, which indicates the rate of longitudinal expansion of the LV, is reduced in patients with impaired diastolic relaxation. With the intention of relating the trans-mitral flow to mitral annulus plane dynamics, we measured mitral annulus recoil force for different valve sizes, while applying an exponential pressure drop in a simplified model of the ventricle. The temporal changes in diameter of the valve during rapid filling phase were also considered. The process of ventricular vortex formation was studied together with the measurement of mitral annulus recoil force within different pressure drop conditions. Matching the vorticity contour plots with the recoil force measurements resulted in the fact that the magnitude of recoil is maximal once the vortex ring is about to pinch off, regardless of the valve size or the characteristics of ventricular pressure drop. This study showed that the mitral annulus recoil is maximal once occurs at the vortex formation time ranging from 3.5 to 4.5. It was also shown that the presence of leaflets would dissipate the annulus recoil force.

Keywords

Vortex ring Vortex formation time Left ventricle Diastole Mitral annulus recoil 

Copyright information

© Biomedical Engineering Society 2007

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringUniversity of South CarolinaColumbiaUSA
  2. 2.Cardiovascular and Biofluid Dynamics LaboratoryCalifornia Institute of TechnologyPasadenaUSA

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