A Computational Parameter Study of Embryo Transfer
Embryo transfer (ET) is the final component of the in vitro fertilization process, and the limiting component to its success rate. The procedure is characterized by considerable technical variations in clinical practice and the effects of these different variations on the overall outcome is little understood. In this article we simulate the embryo transfer procedure based on a 2-dimensional fluid dynamics model and, in a large computational effort, we investigate the sensitivity of embryo placement on an array of procedural parameters. The results support the consensus among practitioners in what is the best choice of procedural factors. Based on the study we propose a set of optimal parameters with which to perform the ET procedure; in addition we suggest a novel technique of volume replacement prior to the catheter withdrawal.
KeywordsEmbryo implantation Uterine transport Fluid dynamics simulation Catheter volume replacement In vitro fertilization
The authors are grateful to Professor Albert Milani for his interest, suggestions and encouragements.
- 3.Bilalis, D., S. A. Marangou, N. Polidoropoulus, P. Sissi, M. Argyrou, S. Doriza, S. Davies, A. Antonakopoulus, and M. Mastrominas. Use of different loading techniques for embryo transfer increasing the risk of ectopic pregnancy. Human Reprod. (Abstract Book, P-479), 17, 162, 2002.Google Scholar
- 7.Griebel, M., T. Dornseifer, and T. Neunhoeffer. Numerical Simulation in Fluid Dynamics, A Practical Approach. Society for Industrial and Applied Mathematics Press, Philadelphia, 1998.Google Scholar