Annals of Biomedical Engineering

, Volume 34, Issue 6, pp 1061–1068

Development of an Advanced Hyperspectral Imaging (HSI) System with Applications for Cancer Detection

  • Matthew E. Martin
  • Musundi B. Wabuyele
  • Kui Chen
  • Paul Kasili
  • Masoud Panjehpour
  • Mary Phan
  • Bergein Overholt
  • Glenn Cunningham
  • Dale Wilson
  • Robert C. DeNovo
  • Tuan Vo-Dinh
Article

DOI: 10.1007/s10439-006-9121-9

Cite this article as:
Martin, M.E., Wabuyele, M.B., Chen, K. et al. Ann Biomed Eng (2006) 34: 1061. doi:10.1007/s10439-006-9121-9

An advanced hyper-spectral imaging (HSI) system has been developed having obvious applications for cancer detection. This HSI system is based on state-of-the-art liquid crystal tunable filter technology coupled to an endoscope. The goal of this unique HSI technology being developed is to obtain spatially resolved images of the slight differences in luminescent properties of malignant versus non-malignant tissues. In this report, the development of the instrument is discussed and the capability of the instrument is demonstrated by observing mouse carcinomas in-vivo. It is shown that the instrument successfully distinguishes between normal and malignant mouse skin. It is hoped that the results of this study will lead to advances in the optical diagnosis of cancer in humans.

Keywords

Hyperspectral imaging (HSI) Fluorescence imaging, Biomedical optics Laser-induced fluorescence 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Matthew E. Martin
    • 1
  • Musundi B. Wabuyele
    • 1
  • Kui Chen
    • 1
  • Paul Kasili
    • 1
  • Masoud Panjehpour
    • 2
  • Mary Phan
    • 2
  • Bergein Overholt
    • 2
  • Glenn Cunningham
    • 3
  • Dale Wilson
    • 3
  • Robert C. DeNovo
    • 4
  • Tuan Vo-Dinh
    • 1
    • 5
    • 6
  1. 1.Center for Advanced Biomedical PhoronicsLife Sciences Division, Oak Ridge National LaboratoryTennesseeNorth Carolina
  2. 2.Thompson Cancer Survival CenterKnoxvilleNorth Carolina
  3. 3.Mechanical Engineering DepartmentTennessee Technological UniversityCookevilleNorth Carolina
  4. 4.Department of Small Animal Clinical SciencesUniversity of Tennessee Veterinary SchoolKnoxvilleNorth Carolina
  5. 5.Fitzpatrick Institute for PhotonicsDuke UniversityDurhamNorth Carolina
  6. 6.Present Adress: Fitzpatrick Institute for PhotonicsDuke UniversityDurhamNorth Carolina

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