Annals of Biomedical Engineering

, Volume 34, Issue 1, pp 59–74

Nanotechnology for Cell–Substrate Interactions

  • Nathan J. Sniadecki
  • Ravi A. Desai
  • Sami Alom Ruiz
  • Christopher S. Chen
Nanobioengineering

Abstract

In the pursuit to understand the interaction between cells and their underlying substrates, the life sciences are beginning to incorporate micro- and nanotechnology-based tools to probe and measure cells. The development of these tools portends endless possibilities for new insights into the fundamental relationships between cells and their surrounding microenvironment that underlie the physiology of human tissue. Here, we review techniques and tools that have been used to study how a cell responds to the physical factors in its environment. We also discuss unanswered questions that could be addressed by these approaches to better elucidate the molecular processes and mechanical forces that dominate the interactions between cells and their physical scaffolds.

Keywords

Cell mechanics Cell shape Extracellular Matrix Focal Adhesions Integrins Mechanotransduction Micropatterning Nanotopology Self-Assembled Monolayers (SAMs) Traction Forces 

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Copyright information

© Biomedical Engineering Society 2005

Authors and Affiliations

  • Nathan J. Sniadecki
    • 1
  • Ravi A. Desai
    • 1
  • Sami Alom Ruiz
    • 1
    • 2
  • Christopher S. Chen
    • 1
  1. 1.Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimoreUSA

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