Annals of Biomedical Engineering

, Volume 34, Issue 1, pp 15–22 | Cite as

Metal Nanoshells

  • Leon R. Hirsch
  • Andre M. Gobin
  • Amanda R. Lowery
  • Felicia Tam
  • Rebekah A. Drezek
  • Naomi J. Halas
  • Jennifer L. West

Metal nanoshells are a new class of nanoparticles with highly tunable optical properties. Metal nanoshells consist of a dielectric core nanoparticle such as silica surrounded by an ultrathin metal shell, often composed of gold for biomedical applications. Depending on the size and composition of each layer of the nanoshell, particles can be designed to either absorb or scatter light over much of the visible and infrared regions of the electromagnetic spectrum, including the near infrared region where penetration of light through tissue is maximal. These particles are also effective substrates for surface-enhanced Raman scattering (SERS) and are easily conjugated to antibodies and other biomolecules. One can envision a myriad of potential applications of such tunable particles. Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents.


Nanotechnology immunoassay controlled release optical imaging cancer 


  1. 1.
    Aden, A. L., and M. Kerker. J. Appl. Phys. 22:1242–1246, 1951.CrossRefGoogle Scholar
  2. 2.
    Amin, Z., W. Thurrell, G. M. Spencer, S. A. Harries, W. E. Grant, S. G. Bown, W. R. Lees. Invest. Radiol. 28:1148–1154, 1993.PubMedCrossRefGoogle Scholar
  3. 3.
    Averitt, R. D., D. Sarkar, and N. J. Halas. Phys. Rev. Lett. 78:4217–4220, 1997.CrossRefGoogle Scholar
  4. 4.
    Averitt, R. D., S. L. Westcott, and N. J. Halas. J. Opt. Soc. Am. B 16:1824–1832, 1999.CrossRefGoogle Scholar
  5. 5.
    Bohren, C. F., and D. R. Huffman. In Absorption and Scattering of Light by Small Particles, Wiley-Interscience, New York, pp. 379, 1983.Google Scholar
  6. 6.
    Eichner, K. Int. Dent. J. 33:1–10, 1983.PubMedGoogle Scholar
  7. 7.
    Fujimoto, J. G., M. E. Brezinski, B. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson. Nat. Med. 1:970–972, 1995.CrossRefPubMedGoogle Scholar
  8. 8.
    Gazelle, G. S., S. N. Goldberg, L. Solbiati, and T. Livraghi. Radiology 217:633–646, 2000.PubMedGoogle Scholar
  9. 9.
    Hagman, H. Dent. Lab. Rev. 54:28–30, 1979.Google Scholar
  10. 10.
    Hilger, I., R. Hiergeist, R. Hergt, K. Winnefeld, H. Schubert, and W. A. Kaiser. Invest. Radiol. 37:580–586, 2002.CrossRefPubMedGoogle Scholar
  11. 11.
    Hirsch, L. R., J. B. Jackson, A. Lee, N. J. Halas, and J. L. West. Analyt. Chem. 75:2377–2381, 2003.CrossRefGoogle Scholar
  12. 12.
    Hirsch, L. R., R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West. Proc. Natl. Acad. Sci. USA 100:13549–13554, 2003.CrossRefPubMedGoogle Scholar
  13. 13.
    Holstrum, N., P. Nilsson, J. Carlsten, and S. Bowland. Biosensors and Bioelectronics 13:1287–1295, 1998.CrossRefPubMedGoogle Scholar
  14. 14.
    Horisberger, M., and J. Rosset. J. Histochem. Cytochem. 25:295–305, 1977.PubMedGoogle Scholar
  15. 15.
    Houten, J. V., D. Benaron, S. Spilman, and D. K. Stevenson. Ped. Res. 39:470–476, 1996.CrossRefGoogle Scholar
  16. 16.
    Huang, D., E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto. Science 254:1178–1181, 1991.PubMedCrossRefGoogle Scholar
  17. 17.
    Jackson, J. B., S. L. Westcott, L. R. Hirsch, J. L. West, and N. J. Halas. Appl. Phys. Lett. 82:257–259, 2003.CrossRefGoogle Scholar
  18. 18.
    Jackson, J. B., and N. J. Halas. Proc. Natl. Acad. Sci. USA 101:17930–17935, 2004.CrossRefPubMedGoogle Scholar
  19. 19.
    Jolesz, F. A., and K. Hynynen. Cancer J. S1:100–112, 2002.Google Scholar
  20. 20.
    Leuvering J. H., Thal P. J., van der Waart M., Schuurs A. H. J. Immunoassay, 1:77–91, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Lindholm-Sethson, B., J. C. Gonzalez, and G. Puu. Langmuir 14:6705–6708, 1998.CrossRefGoogle Scholar
  22. 22.
    Loo, C., A. Lowery, N. Halas, J. West, and R. Drezek. NanoLett. 5:709–711, 2005.Google Scholar
  23. 23.
    Maeda, H., T. Sawa, and T. Konno. J. Control. Rel. 74:46–61, 2001.Google Scholar
  24. 24.
    Maher, R. C., L. F. Cohen, P. Etchegoin, H. J. N. Hartigan, R. J. C. Brown, and M. J. T. Milton. J. Chem. Phys. 120:11746–11753, 2004.CrossRefPubMedGoogle Scholar
  25. 25.
    Nuzzo, R. G., F. A. Fusco, and D. L. Allara. J. Am. Chem. Soc. 109:2358–2368, 1987.CrossRefGoogle Scholar
  26. 26.
    Oldenburg, S. J., R. D. Averitt, S. L. Westcott, and N. J. Halas. Chem. Phys. Lett. 28:243–247, 1998.CrossRefGoogle Scholar
  27. 27.
    Oldenburg, S. J., S. L. Westcott, R. D. Averitt, and N. J. Halas. J. Chem. Phys. 111:4729–4735, 1999.CrossRefGoogle Scholar
  28. 28.
    O'Neal, D. P., L. R. Hirsch, N. J. Halas, J. D. Payne, and J. L. West. Cancer Lett., In Press, 2004.Google Scholar
  29. 29.
    Pourbaix, M. Biomaterials 5:122–134, 1984.CrossRefPubMedGoogle Scholar
  30. 30.
    Priest, J. H., S. L. Murray, R. J. Nelson, and A. S. Hoffman. Revers. Polym. Gels Relat. Syst. 350:255–264, 1987.CrossRefGoogle Scholar
  31. 31.
    Prodan, E., C. Radloff, N. Halas, and P. Nordlander, Science 302:419–422, 2003.CrossRefPubMedGoogle Scholar
  32. 32.
    Quinten, M. Appl. Phys. B 73:317–326, 2001.CrossRefGoogle Scholar
  33. 33.
    Rajadhyaksha, M., S. González, J. M. Zavislan, R. R. Anderson, and R. H. Webb. J. Invest. Dermatol. 113:203–303, 1999.CrossRefGoogle Scholar
  34. 34.
    Ruan, C., R. Yang, X. Chen, and J. Deng. J. Electroanal. Chem. 455:121–125, 1998.CrossRefGoogle Scholar
  35. 35.
    Sasaki, S., H. Kawasaki, and H. Maeda. Macromolecules 30:1847–1848, 1997.CrossRefGoogle Scholar
  36. 36.
    Seki, T., M. Wakabayashi, T. Nakagawa, M. Imamura, T. Tamai, A. Nishimura, N. Yamashiki, A. Okamura, and K. Inoue. Cancer 85:1694–1702, 1999.CrossRefPubMedGoogle Scholar
  37. 37.
    Singer J. M. and Plotz, C. M. Am. J. Med. 21:888–892, 1956.CrossRefPubMedGoogle Scholar
  38. 38.
    Sershen, S., and J. West. Adv. Drug Del. Rev. 54:1225–1235, 2002.CrossRefGoogle Scholar
  39. 39.
    Sershen, S. R., J. L. Westcott, J. L. West, and N. J. Halas. Appl. Phys. B 73:379–381, 2001.CrossRefGoogle Scholar
  40. 40.
    Sershen S. R., Mensing G. A., Ng M., Halas N. J., Beebe D. J. West J. L. Adv. Mat., 17:1366–1368, 2005.CrossRefGoogle Scholar
  41. 41.
    Sershen, S. R., S. L. Westcott, N. J. Halas, and J. L. West. J. Biomed. Mater. Res. 51:293–298, 2000.CrossRefPubMedGoogle Scholar
  42. 42.
    Sershen, S. R., S. L. Westcott, N. J. Halas, and J. L. West. Appl. Phys. Lett. 80:4609–4611, 2002.CrossRefGoogle Scholar
  43. 43.
    Sokolov, K., M. Follen, I. Pavolva, A. Malpica, R. Lotan, and R. Richards-Kortum. Cancer Res. 63:1999–2004, 2003.PubMedGoogle Scholar
  44. 44.
    Stober, W., and A. Fink. J. Colloid. Interf. Sci. 26:62–69, 1968.CrossRefGoogle Scholar
  45. 45.
    Tanaka, N., S. Matsukawa, H. Kuroso, and I. Ando. Polymer 39:4703–4706, 1998.CrossRefGoogle Scholar
  46. 46.
    Vogel, A. Phys. Med. Biol. 42:895–912, 1997.CrossRefPubMedGoogle Scholar
  47. 47.
    Vogl, T. J., M. G. Mack, R. Straub, K. Engelmann, S. Zangos, and K. Eichler. Radiologe 39:764–771, 1999.CrossRefPubMedGoogle Scholar
  48. 48.
    Wang, Y., X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang. NanoLett. 4:1689–1692, 2004.Google Scholar
  49. 49.
    Weissleder, R. Nat. Biotech. 19:316–317, 2001.CrossRefGoogle Scholar
  50. 50.
    Welch, A., and M. van Gemert (Eds). Optical-Thermal Response of Laser-Irradiated Tissue, Plenum Press, New York, 1995.Google Scholar
  51. 51.
    Yoshida, R., K. Sakai, T. Okano, and Y. Sakurai. J. Biomat. Sci. Polym. Ed. 6:585–598, 1994.Google Scholar
  52. 52.
    Zhou, H. S., I. Honma, and H. Komiyama. Phys. Rev. B 50:12052–12056, 1994.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Leon R. Hirsch
    • 1
  • Andre M. Gobin
    • 1
  • Amanda R. Lowery
    • 1
  • Felicia Tam
    • 2
  • Rebekah A. Drezek
    • 1
  • Naomi J. Halas
    • 2
  • Jennifer L. West
    • 1
  1. 1.Department of BioengineeringRice UniversityHoustonUSA
  2. 2.Department of Electrical and Computer EngineeringHoustonUSA

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