Annals of Biomedical Engineering

, Volume 33, Issue 2, pp 214–222

Diffusivity and Solubility of Nitric Oxide in Water and Saline


DOI: 10.1007/s10439-005-8980-9

Cite this article as:
Zacharia, I.G. & Deen, W.M. Ann Biomed Eng (2005) 33: 214. doi:10.1007/s10439-005-8980-9


Aqueous diffusivities and solubilities of NO were determined by using a chemiluminescence detector to measure time-dependent fluxes across stagnant liquid films confined between polydimethylsiloxane membranes. The NO diffusivities in pure water and PBS at 25C were found to be (2.21 ± 0.02) × 10−5 cm2 s−1 and (2.21 ± 0.04) × 10−5 cm2 s−1, respectively. Although lower than most previous values for NO at room temperature, these diffusivities are very similar to those for O2, as one would expect. Extrapolation to 37°C yielded a value of 3.0 × 10−5 cm2 s−1. The solubility of NO in water at 25°C was (1.94 ± 0.03) × 10−6 mol cm−3 atm−1, in agreement with the literature. This agreement, along with the excellent fits obtained to the transient flux data (<4% rms error in each experiment), supports the validity of the simultaneously measured diffusivity. The solubility of NO in PBS at 25°C was (1.75 ± 0.02) × 10−6 mol cm−3 atm−1. The modest (10%) reduction in solubility relative to that in pure water is consistent with the usual effects of salts on gas solubilities.


Diffusion of dissolved gases Silastic Chemiluminescence detection 

Copyright information

© Biomedical Engineering Society 2005

Authors and Affiliations

  1. 1.Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridge
  2. 2.Biological Engineering DivisionMassachusetts Institute of TechnologyCambridge

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