Annals of Biomedical Engineering

, Volume 33, Issue 12, pp 1719–1723 | Cite as

Cellular Fluid Mechanics and Mechanotransduction

  • John M. Tarbell
  • Sheldon Weinbaum
  • Roger D. Kamm
Article

Abstract

Mechanotransduction, the transformation of an applied mechanical force into a cellular biomolecular response, is briefly reviewed focusing on fluid shear stress and endothelial cells. Particular emphasis is placed on recent studies of the surface proteoglycan layer (glycocalyx) as a primary sensor of fluid shear stress that can transmit force to apical structures such as the plasma membrane or the actin cortical web where transduction can take place or to more remote regions of the cell such as intercellular junctions and basal adhesion plaques where transduction can also occur. All of these possibilities are reviewed from an integrated perspective.

Keywords

Shear stress Endothelial cells Mechanotransduction Glycocalyx Cytoskeleton 

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Copyright information

© Biomedical Engineering Society 2005

Authors and Affiliations

  • John M. Tarbell
    • 1
    • 3
  • Sheldon Weinbaum
    • 1
  • Roger D. Kamm
    • 2
  1. 1.Department of Biomedical EngineeringCity College of New YorkNew York
  2. 2.Departments of Mechanical and Biological EngineeringMassachusetts Institute of TechnologyCambridge
  3. 3.Department of Biomedical EngineeringCity College of New YorkNew York

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