Annals of Biomedical Engineering

, Volume 32, Issue 12, pp 1599–1606 | Cite as

Nonhomogeneous Deformation in the Anterior Leaflet of the Mitral Valve

  • Ling Chen
  • Andrew D. McCulloch
  • Karen May-Newman


In the mitral valve, regional variations in structure and material properties combine to affect the biomechanics of the entire valve. Previous biaxial testing has shown that mitral valve leaflet tissue is highly extensible, and exhibits nonlinear, anisotropic material properties. In this study, experimental measurements of mitral valve leaflet deformation under quasi-static pressure loading were performed on isolated porcine hearts. Biplane video images of markers placed on the anterior leaflet surface were used to reconstruct the 3D position of the markers at several pressure levels over the physiological range. A least-squares finite-element method was used to fit parametric models to the markers and to calculate the deformation over the surface. The results showed that the leaflet deformations were anisotropic, exhibiting a large nonhomogeneous radial stretch and a small circumferential stretch. This information can be used to better understand how the valve deforms under physiological loading, and to help design treatments for valve problems, such as mitral regurgitation.

Stretch ratio Least squares Pressure loading Mitral annulus Coaptation line 


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Copyright information

© Biomedical Engineering Society 2004

Authors and Affiliations

  • Ling Chen
    • 1
  • Andrew D. McCulloch
    • 2
  • Karen May-Newman
    • 1
  1. 1.Department of Mechanical EngineeringSan Diego State UniversitySan DiegoCA
  2. 2.Department of BioengineeringUniversity of CaliforniaSan DiegoCA

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