Annals of Surgical Oncology

, Volume 7, Issue 10, pp 738–742

Prognostic Indicators in Melanoma of the Vulva

  • Francesco Raspagliesi
  • Antonino Ditto
  • Dario Paladini
  • Rosanna Fontanelli
  • Bernardina Stefanon
  • Silvana DiPalma
  • Giuseppe De Palo
Editorial

DOI: 10.1007/s10434-000-0738-x

Cite this article as:
Raspagliesi, F., Ditto, A., Paladini, D. et al. Ann Surg Oncol (2000) 7: 738. doi:10.1007/s10434-000-0738-x

Abstract

Background: The aim of this study was to evaluate the prognostic significance of clinicalpathologic variables in melanoma of the vulva.

Methods: From 1979 through 1995, 40 women with a diagnosis of vulvar melanoma underwent radical surgery. Patient age, tumor size and site, histologic type, ulceration, tumor thickness, lymph node status, and number of positive lymph nodes were assessed for prognostic significance by multivariate analysis.

Results: Tumor thickness was a significant predictor of lymph node involvement, but not of survival. The most powerful predictors of survival by multivariate analysis were the lymph node status (P 5 .002) and the number of positive lymph nodes (P 5 .00003).

Conclusions: The number of positive lymph nodes represents the strongest prognostic factor in melanoma of the vulva. Because of the lack of effective adjuvant therapies, such prognostic indicators might be used to define the timing and extent of the surgical approach.

Key Words

Malignant melanoma Vulvar neoplasm Prognostic factors Survival. 

Copyright information

© The Society of Surgical Oncology, Inc. 2000

Authors and Affiliations

  • Francesco Raspagliesi
    • 1
  • Antonino Ditto
    • 1
  • Dario Paladini
    • 1
    • 4
  • Rosanna Fontanelli
    • 1
  • Bernardina Stefanon
    • 2
  • Silvana DiPalma
    • 3
  • Giuseppe De Palo
    • 1
  1. 1.Departments of Gynecologic OncologyIstituto Nazionale TumoriMilanItaly
  2. 2.Departments of Surgical Semeiotics and Ambulatory SurgeryIstituto Nazionale TumoriMilan
  3. 3.Department of Gynecology PathologyIstituto Nazionale TumoriMilan
  4. 4.Department of Gynecology and ObstetricsUniversity of NaplesNaplesItaly

Personalised recommendations