European Radiology Supplements

, Volume 17, Supplement 6, pp 89–98

Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment

  • Nathalie Lassau
  • Linda Chami
  • Baya Benatsou
  • Pierre Peronneau
  • Alain Roche
Achieving Optimal Diagnostic Yield Using Real-Time CEUS

DOI: 10.1007/s10406-007-0233-6

Cite this article as:
Lassau, N., Chami, L., Benatsou, B. et al. Eur Radiol Suppl (2007) 17(Suppl 6): 89. doi:10.1007/s10406-007-0233-6

Abstract

Dynamic contrast-enhanced ultrasonography (DCEUS) using the contrast agent Sonovue and vascular recognition imaging software is a novel technique that enables the detection of microvessels and quantitative assessment of solid tumor perfusion using raw linear data. Clinical trials have shown that DCE-US can be used to assess the anticancer efficacy of antiangiogenic treatment, for which conventional efficacy criteria based on size are unsuitable. Reduction in tumor vascularization can easily be detected in responders after 1–2 weeks and is correlated with progression-free survival and overall survival. DCE-US is supported by the French Cancer National Institut. This program is currently studying the technique in metastatic breast cancer, melanoma, colon cancer, gastrointestinal stromal tumor, and renal cell carcinoma, as well as in primary hepatocellular carcinoma, to establish the optimal perfusion parameters and timing for quantitative anticancer efficacy assessments.

Keywords

Dynamic contrast-enhanced ultrasonography Tumor perfusion quantification Antiangiogenic treatments 

Copyright information

© European Society of Radiology 2007

Authors and Affiliations

  • Nathalie Lassau
    • 1
  • Linda Chami
    • 1
  • Baya Benatsou
    • 1
  • Pierre Peronneau
    • 1
  • Alain Roche
    • 1
  1. 1.Imaging Department and Imaging Laboratory of Small AnimalsUPRES EA 40-40 Institut Gustave-RoussyVillejuifFrance

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