Der Pneumologe

, Volume 10, Issue 4, pp 258–259

Die DREAM-Studie – Abschluss einer Selbstfindung und Beginn einer Zeitenwende

Journal Club

The DREAM study – completion of a self-discovery and the beginning of a new era

Literatur

  1. 1.
    Hogan SP, Foster PS (1997) Cytokines as targets for the inhibition of eosinophilic inflammation. Pharmacol Ther 74:259–283PubMedCrossRefGoogle Scholar
  2. 2.
    Leckie MJ (2003) Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models. Am J Respir Med 2:245–259PubMedCrossRefGoogle Scholar
  3. 3.
    Leckie MJ, Brinke A ten, Khan J et al (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356:2144–2148PubMedCrossRefGoogle Scholar
  4. 4.
    Lommatzsch M, Julius P, Kuepper M et al (2006) The course of allergen-induced leukocyte infiltration in human and experimental asthma. J Allergy Clin Immunol 118:91–97PubMedCrossRefGoogle Scholar
  5. 5.
    Wenzel SE (2012) Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 18:716–725PubMedCrossRefGoogle Scholar
  6. 6.
    Nair P, Pizzichini MM, Kjarsgaard M et al (2009) Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 360:985–993PubMedCrossRefGoogle Scholar
  7. 7.
    Haldar P, Brightling CE, Hargadon B et al (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360:973–984PubMedCrossRefGoogle Scholar
  8. 8.
    Pavord ID, Korn S, Howarth P et al (2012) Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380:651–659PubMedCrossRefGoogle Scholar
  9. 9.
    Garcia G, Magnan A, Chiron L et al (2013) A proof of concept randomized-controlled trial of omalizumab in patients with severe difficult to control nonathopic asthma. Chest (im Druck) Google Scholar
  10. 10.
    Lommatzsch M, Korn S, Buhl R et al (2013) Against all odds: anti-IgE for intrinsic asthma? Thorax (im Druck)Google Scholar
  11. 11.
    Corren J, Lemanske RF, Hanania NA et al (2011) Lebrikizumab treatment in adults with asthma. N Engl J Med 365:1088–1098PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Abteilung für Pneumologie, Zentrum für Innere MedizinUniversität RostockRostockDeutschland

Personalised recommendations