Der Pneumologe

, Volume 2, Issue 1, pp 8–16 | Cite as

Ambulant erworbene Pneumonie

Wie viel Diagnostik muss sein?
Leitthema
  • 73 Downloads

Zusammenfassung

Eine rationale Diagnostik der ambulant erworbenen Pneumonie soll dem Arzt helfen, eine definitive Diagnose zu stellen, den verantwortlichen Erreger zu bestimmen und eine Aussage über die Prognose zu treffen. „Gold-Standard“ in der Diagnosestellung ist neben anamnestischen und klinischen Befunden weiterhin die Röntgenaufnahme der Thoraxorgane. Moderne Entzündungsmarker wie das C-reaktive Protein und in Zukunft möglicherweise das Prokalzitonin sind wichtig für die Differenzialdiagnose und Verlaufsuntersuchung. Die mögliche Erregerdiagnostik umfasst neben der klassischen Kultur neuere Urinantigentests gegen Streptococcus pneumoniae und Legionella pneumophila. Ein einfacher klinischer Prognosescore hilft dem Arzt bei der Entscheidung, welcher Patient ins Krankenhaus eingewiesen werden sollte.

Schlüsselwörter

Ambulant erworbene Pneumonie Erregerdiagnostik Prokalzitonin Legionellen-Urinantigen Prognosescore 

Community-acquired pneumonia

How much diagnostic work-up is necessary?

Abstract

Diagnostic tools are essential for the physician to reach a correct diagnosis of community-acquired pneumonia, to determine the pathogen, and to estimate the prognosis of individual patients. X-ray of the chest remains the “gold standard” for identification of pneumonia. Modern inflammatory markers such as C-reactive protein and in the future procalcitonin are essential for the differential diagnosis and follow-up. The microbiology tests include, besides classic bacterial cultures, urinary antigen tests for Streptococcus pneumoniae and Legionella pneumophila. A simple prognostic score has been developed to help the physician to decide if the patient needs hospitalization.

Keywords

Community-acquired pneumonia Microbiology Procalcitonin Legionella urinary antigen Prognostic score 

Notes

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Literatur

  1. 1.
    Almirall J, Bolibar I, Toran P et al. (2004) Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest 125:1335–1342CrossRefGoogle Scholar
  2. 2.
    Angus DC, Marrie TJ, Obrosky DS et al. (2002) Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria. Am J Respir Crit Care Med 166:717–723CrossRefGoogle Scholar
  3. 3.
    Bartlett JG (2004) Decline in microbial studies for patients with pulmonary infections. Clin Infect Dis 39:170–172CrossRefGoogle Scholar
  4. 4.
    Basi SK, Marrie TJ, Huang JQ, Majumdar SR (2004) Patients admitted to hospital with suspected pneumonia and normal chest radiographs: epidemiology, microbiology, and outcomes. Am J Med 117:305–311CrossRefGoogle Scholar
  5. 5.
    Butler JC, Bosshardt SC, Phelan M et al. (2003) Classical and latent class analysis evaluation of sputum polymerase chain reaction and urine antigen testing for diagnosis of pneumococcal pneumonia in adults. J Infect Dis 187:1416–1423CrossRefGoogle Scholar
  6. 6.
    Castro-Guardiola A, Armengou-Arxe A, Viejo-Rodriguez A et al. (2000) Differential diagnosis between community-acquired pneumonia and non-pneumonia diseases of the chest in the emergency ward. Eur J Intern Med 11:334–339CrossRefGoogle Scholar
  7. 7.
    Christ-Crain M, Jaccard-Stolz D, Bingisser R et al. (2004) Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 363:600–607CrossRefGoogle Scholar
  8. 8.
    Corbo J, Friedman B, Bijur P, Gallagher EJ (2004) Limited usefulness of initial blood cultures in community acquired pneumonia. Emerg Med J 21:446–448Google Scholar
  9. 9.
    Dominguez J, Gali N, Blanco S et al. (2001) Urinary antigen test for pneumococcal pneumonia. Chest 120:1748–1750CrossRefGoogle Scholar
  10. 10.
    Fine MJ, Smith MA, Carson CA et al. (1996) Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA 275:134–141CrossRefPubMedGoogle Scholar
  11. 11.
    Garcia-Ordonez MA, Garcia-Jimenez JM, Paez F et al. (2001) Clinical aspects and prognostic factors in elderly patients hospitalised for community-acquired pneumonia. Eur J Clin Microbiol Infect Dis 20:14–19CrossRefGoogle Scholar
  12. 12.
    Garcia Vazquez E, Martinez JA, Mensa J et al. (2003) C-reactive protein levels in community-acquired pneumonia. Eur Respir J 21:702–705Google Scholar
  13. 13.
    Garcia-Vazquez E, Marcos MA, Mensa J et al. (2004) Assessment of the usefulness of sputum culture for diagnosis of community-acquired pneumonia using the PORT predictive scoring system. Arch Intern Med 164:1807–1811CrossRefGoogle Scholar
  14. 14.
    Gutierrez F, Masia M, Rodriguez JC et al. (2003) Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. Clin Infect Dis 36:286–292CrossRefGoogle Scholar
  15. 15.
    Hamer DH, Egas J, Estrella B et al. (2002) Assessment of the Binax NOW Streptococcus pneumoniae urinary antigen test in children with nasopharyngeal pneumococcal carriage. Clin Infect Dis 34:1025–1028CrossRefPubMedGoogle Scholar
  16. 16.
    Hansson LO, Hedlund JU, Ortqvist AB (1997) Sequential changes of inflammatory and nutritional markers in patients with community-acquired pneumonia. Scand J Clin Lab Invest 57:111–118Google Scholar
  17. 17.
    Kauppinen MT, Lahde S, Syrjala H (1996) Roentgenographic findings of pneumonia caused by Chlamydia pneumoniae. A comparison with streptococcus pneumonia. Arch Intern Med 156:1851–1856CrossRefGoogle Scholar
  18. 18.
    Lettinga KD, Verbon A, Weverling GJ et al. (2002) Legionnaires‘ disease at a Dutch flower show: prognostic factors and impact of therapy. Emerg Infect Dis 8:1448–1454Google Scholar
  19. 19.
    Lim WS, Macfarlane JT, Boswell TC et al. (2001) Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax 56:296–301CrossRefPubMedGoogle Scholar
  20. 20.
    Lim WS, van der Eerden MM, Laing R et al. (2003) Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 58:377–382CrossRefPubMedGoogle Scholar
  21. 21.
    Lindsay DS, Abraham WH, Findlay W et al. (2004) Laboratory diagnosis of legionnaires‘ disease due to Legionella pneumophila serogroup 1: comparison of phenotypic and genotypic methods. J Med Microbiol 53:183–187CrossRefGoogle Scholar
  22. 22.
    Mandell LA, Bartlett JG, Dowell SF et al. (2003) Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 37:1405–1433CrossRefPubMedGoogle Scholar
  23. 23.
    Marcos MA, Jimenez de Anta MT, de la Bellacasa JP et al. (2003) Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults. Eur Respir J 21:209–214CrossRefGoogle Scholar
  24. 24.
    Muller CA, Uhl W, Printzen G et al. (2000) Role of procalcitonin and granulocyte colony stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. Gut 46:233–238CrossRefGoogle Scholar
  25. 25.
    Murdoch DR, Laing RT, Cook JM (2003) The NOW S. pneumoniae urinary antigen test positivity rate 6 weeks after pneumonia onset and among patients with COPD. Clin Infect Dis 37:153–154CrossRefGoogle Scholar
  26. 26.
    Reed WW, Byrd GS, Gates RH Jr et al. (1996) Sputum gram’s stain in community-acquired pneumococcal pneumonia. A meta-analysis. West J Med 165:197–204Google Scholar
  27. 27.
    Roson B, Carratala J, Verdaguer R et al. (2000) Prospective study of the usefulness of sputum Gram stain in the initial approach to community-acquired pneumonia requiring hospitalization. Clin Infect Dis 31:869–874CrossRefGoogle Scholar
  28. 28.
    Roson B, Fernandez-Sabe N, Carratala J et al. (2004) Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia.Clin Infect Dis 38:222–226CrossRefGoogle Scholar
  29. 29.
    Schaberg T, Dalhoff K, Lorenz J et al. (1997) Deutsche Gesellschaft für Pneumologie: Empfehlung zur Diagnostik der ambulant erworbenen Pneumonie. Pneumologie 51:69–77Google Scholar
  30. 30.
    Seppa Y, Bloigu A, Honkanen PO et al. (2001) Severity assessment of lower respiratory tract infection in elderly patients in primary care. Arch Intern Med 161:2709–2713CrossRefGoogle Scholar
  31. 31.
    Smith MD, Derrington P, Evans R et al. (2003) Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation. J Clin Microbiol 41:2810–2813CrossRefGoogle Scholar
  32. 32.
    Syrjala H, Broas M, Suramo I et al. (1998) High-resolution computed tomography for the diagnosis of community-acquired pneumonia. Clin Infect Dis 27:358–363Google Scholar
  33. 33.
    Theerthakarai R, El-Halees W, Ismail M et al. (2001) Nonvalue of the initial microbiological studies in the management of nonsevere community-acquired pneumonia. Chest 119:181–184CrossRefGoogle Scholar
  34. 34.
    Waterer GW, Wunderink RG (2001) The influence of the severity of community-acquired pneumonia on the usefulness of blood cultures. Respir Med 95:78–82CrossRefGoogle Scholar
  35. 35.
    Woodhead MA, Macfarlane JT, McCracken JS et al. (1987) Prospective study of the aetiology and outcome of pneumonia in the community. Lancet 1:671–674CrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag 2004

Authors and Affiliations

  1. 1.Medizinische Klinik IIIUniversitätsklinikum Schleswig-Holstein, Campus Lübeck
  2. 2.Medizinische Klinik IIIUniversitätsklinikum Schleswig-Holstein (UKSH), Campus LübeckLübeck

Personalised recommendations