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An innovative micro magnetic separator based on 3D micro-copper-coil exciting soft magnetic tips and FeNi wires for bio-target sorting

  • Shaotao ZhiEmail author
  • Xuecheng Sun
  • Zhu Feng
  • Chong LeiEmail author
  • Yong Zhou
Research Paper
  • 80 Downloads

Abstract

Manipulation of cells or bio-targets is required in a variety of biological, diagnostic and therapeutic applications. In this paper, we present a novel magnetic separator for magnetic bead labeled-target sorting in microfluidic systems. This micro magnetic separator includes 3D micro copper coil, soft magnetic tips and FeNi wires. The magnetic tips and FeNi wires are first simulated and optimized by MagNet software to increase the magnetic force exerted on magnetic beads, and fabricated by microfabrication technology. The experiment results show the sorting ratio of the magnetic beads can be up to 92.5% with the current of 200 mA and the flow rate of 5 µL/min. The maximum sorting ratio can reach 78.4% for 100 CFU/mL E. coli O157:H7 sample with the current of 200 mA and the flow rate of 0.5 µL/min. On account of the miniaturization, high sorting efficiency, low excitation current, high level of detection automation and easy integration with micro magnetic sensor, this micro magnetic separation system can be a potential application in bio-target sorting and detecting.

Keywords

3D micro coil Magnetic sorting Magnetic tips FeNi wires 

Notes

Acknowledgements

This work is supported by The National Natural Science Foundation of China (No.61273065), National Science and Technology Support Program (2012BAK08B05), Support fund of Shanghai Jiao Tong University (AgriX2015005), Support fund of Joint research center for advanced aerospace technology of Shanghai Academy of Spaceflight Technology-Shanghai Jiao Tong University (USCAST2015-2), Support fund of aerospace technology (15GFZ-JJ02-05), the Analytical and Testing Center in Shanghai Jiao Tong University, the Center for Advanced Electronic Materials and Devices in Shanghai Jiao Tong University.

Compliance with ethical standards

Conflict of interest

There are no conflicts of interest to declare.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Thin Film and Microfabrication Technology (Ministry of Education), Department of Micro/Nano Electronics, School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiChina

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