Gelatin-based microfluidics device with the feature sizes smaller than 100 µm for production of oil-in-water emulsions

  • Shaohua MaEmail author
Short Communication


Hydrogel-based microfluidics offers the intrinsic hydrophilicity of the embossed microfluidic channels. The previous work on hydrogel-based microfluidics usually has limited access to small features. Here, we offer a solution to fabricate gelatin-based microfluidics device with the feature sizes smaller than 100 µm. The fabrication was straightforward, using gelatin and riboflavin solution, without requiring the chemical functionalization of gelatin towards gelatin methacrylate. The mechanical and thermal stability of gelatin was improved by exposing the gelatin–riboflavin mixture under blue light, which induced chemical crosslinking by photooxidation. The devices were stable enough to produce oil-in-water droplets and oil-in-oil-in-water double emulsions for demanded applications.



The work is funded by Shenzhen Municipal Development and Reform Commission, Shenzhen Engineering Laboratory for Precision Medicine and Healthcare, Grant number: SDRC [2015]1950. The work is also funded by the Scientific Research Start-Up Fund of Tsinghua-Berkeley Shenzhen Institute.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

10404_2019_2203_MOESM1_ESM.mp4 (1.9 mb)
Supplementary material 1 (MP4 1995 KB)
10404_2019_2203_MOESM2_ESM.mp4 (192 kb)
Supplementary material 2 (MP4 191 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Shenzhen Engineering Laboratory for Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen InstituteTsinghua UniversityShenzhenPeople’s Republic of China

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