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Suspension of deformable particles in Newtonian and viscoelastic fluids in a microchannel

  • Amir Hossein Raffiee
  • Sadegh Dabiri
  • Arezoo M. ArdekaniEmail author
Research Paper
Part of the following topical collections:
  1. Particle motion in non-Newtonian microfluidics

Abstract

In this paper, we study a suspension of cells at a moderate volume fraction flowing in a microchannel filled with Newtonian or viscoelastic fluids and investigate the role of cell size, cell volume fraction, inertia, deformability, and fluid elasticity on the cell distribution. Our results suggest that the use of constant-viscosity viscoelastic fluid pushes the cells toward the channel centerline which can be used in microfluidic devices used for cell focusing such as cytometers. The cell-free layer increases which provides larger gap for separating rare cells in microfluidic devices. Furthermore, we show that the volumetric flow rate can be significantly enhanced with the addition of polymers in the suspending fluid. This effect enhances the processing speed which is of interest in designing microfluidic devices. This fundamental study can provide insight on the role of rheological properties of the fluid that can be tuned to control the motion of the cells for efficient design of microfluidic devices.

Keywords

Cell migration in polymeric fluids Cell focusing Elasto-inertial cell migration 

Notes

Acknowledgements

This research was partially supported by a Grant from National Science Foundation [CBET-1705371].

Compliance with ethical standards

Conflict of interest

There are no conflicts of interest to declare.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Amir Hossein Raffiee
    • 1
  • Sadegh Dabiri
    • 1
    • 2
  • Arezoo M. Ardekani
    • 1
    Email author
  1. 1.School of Mechanical EngineeringPurdue UniversityWest LafayetteUSA
  2. 2.Department of Agricultural and Biological EngineeringPurdue UniversityWest LafayetteUSA

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