A temperature-based diagnostic approach for paper-based microfluidics

  • A. TerzisEmail author
  • G. Yang
  • I. Zarikos
  • E. Elizalde
  • B. Weigand
  • A. Kalfas
  • X. Ding
Short Communication


We present the potential of a quantitative temperature-based diagnostic approach for paper-based microfluidics, extending the work of Terzis et al. (J Colloid Interface Sci 504:751–757, 2017) which demonstrated a significant heat release at the liquid front during capillary-driven flows in cellulosic materials. Here, we investigate the applicability of biological fluids to provide a temperature rise at the imbibition front, and successfully demonstrate a monotonic trend between the level of local temperature rise and the concentration of specific analytes. In addition, effects of paper thickness and width are also examined.


Paper-based microfluidics Quantitative diagnostics Capillary thermodynamics 



A. Terzis acknowledges the support of Alexander von Humboldt (AvH) foundation. I. Zarikos acknowledges the support received under the ERC Grant Agreement No. 341225. Special thanks go to Dr. Eleftheria Roumeli (California Institute of Technology) for characterizing the paper samples. The authors are also grateful to Prof. S. Majid Hassanizadeh (Utrecht University) for his overall contribution.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Aerospace Thermodynamics (ITLR)University of StuttgartStuttgartGermany
  2. 2.Environmental Hydrogeology Group, Department of Earth SciencesUniversity of UtrechtUtrechtThe Netherlands
  3. 3.Laboratorio de Fluidodinámica, Facultad de Ingeniería UBACONICETBuenos AiresArgentina
  4. 4.School of EngineeringAristotle University of ThessalonikiThessaloníkiGreece
  5. 5.Institute for Personalised Medicine, School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

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