Microfluidics and Nanofluidics

, Volume 17, Issue 4, pp 647–655

Three-dimensional hydrodynamic flow and particle focusing using four vortices Dean flow

  • Byung Hang Ha
  • Kang Soo Lee
  • Jin Ho Jung
  • Hyung Jin Sung
Research Paper

DOI: 10.1007/s10404-014-1346-6

Cite this article as:
Ha, B.H., Lee, K.S., Jung, J.H. et al. Microfluid Nanofluid (2014) 17: 647. doi:10.1007/s10404-014-1346-6

Abstract

We present a three-dimensional (3D) hydrodynamic focusing device built on a single-layer platform using single sheath flow. Despite the simple structure and operation, the device not only achieves narrow focusing of a sample fluid or particles but also switches the cross-sectional size and lateral position of the sample stream. The focusing mechanism utilizes four Dean vortices generated in a high-speed flow through a curved channel. Theoretical calculations, numerical simulations, and an experimental study demonstrated that the device could focus microparticles that resemble human platelets in terms of particle size and density in a single-stream manner. Further simulation study suggested that the device could focus most cell sizes used in flow cytometry with a throughput of 200,000 cells s−1. In addition, the device can function as a 3D liquid-core/liquid-cladding (L2) optical waveguide by introducing a core liquid with a refractive index higher than that of the cladding.

Keywords

Lab-on-a-chip devices Waveguides Microfluidics Dean vortex Hydrodynamic focusing 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Byung Hang Ha
    • 1
  • Kang Soo Lee
    • 1
  • Jin Ho Jung
    • 1
  • Hyung Jin Sung
    • 1
  1. 1.Department of Mechanical EngineeringKAISTTaejonKorea

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