Enhanced-throughput production of polymersomes using a parallelized capillary microfluidic device
- 1.4k Downloads
We report a parallelized capillary microfluidic device for enhanced production rate of monodisperse polymersomes. This device consists of four independent capillary microfluidic devices, operated in parallel; each device produces monodisperse water-in-oil-in-water (W/O/W) double-emulsion drops through a single-step emulsification. During generation of the double-emulsion drops, the innermost water drop is formed first and it triggers a breakup of the middle oil phase over wide range of flow rates; this enables robust and stable formation of the double-emulsion drops in all drop makers of the parallelized device. Double-emulsion drops are transformed to polymersomes through a dewetting of the amphiphile-laden middle oil phase on the surface of the innermost water drop, followed by the subsequent separation of the oil drop. Therefore, we can make polymersomes with a production rate enhanced by a factor given by the number of drop makers in the parallelized device.
KeywordsMicrofluidics Polymersomes Emulsions Microcapsules Parallelization
This work was supported by Amore-Pacific, the National Science Foundation (DMR-1006546) and the Harvard Materials Research Science and Engineering Center (DMR-0820484).
- Kim SH, Jeon SJ, Jeong WC, Park HS, Yang SM (2008a) Optofluidic synthesis of electroresponsive photonic Janus balls with isotropic structural colors. Adv Mater 20(21):4129–4134Google Scholar