Design and characterization of a platform for thermal actuation of up to 588 microfluidic valves
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In this paper, we describe a large-scale microfluidic valve platform for thermally actuated phase change (PC) microvalves. PC microvalves can be actuated by heat sources such as ohmic resistors, which can be highly integrated resulting in dense arrays of individually addressable microfluidic valves. We present a custom-made electronic platform with custom-written control software that allows controlling a total of 588 individually addressable resistors each of which can be used as the actuator for a separate PC valve. The platform is demonstrated with direct PC microvalve (the simplest example of a PC valve) where working fluid and phase change material are the same media. We present experimental results for single valve setups as well as for a 24 microvalve setup showing the scalability of the system. Furthermore, we demonstrate that precise and individual ‘per-resistor’ temperature profiles are required for valve actuation in order to decrease thermal latency and ensure that the time required for switching the valve state is independent from the “thermal history” (i.e. the duration of the previous valve state) of the valve. To the best of our knowledge, there is no such platform described in the literature, which offers an equal potential for individual valve operation (potentially up to 588 individual valves) as presented in this work.
KeywordsMicrofluidics Microfluidic valves Thermal actuation Phase change
This work was funded in part by the ‚Concept for the Future’ of Karlsruhe Institute of Technology (KIT) within the framework of the German Excellence Initiative, a Max-Buchner Research fellowship (DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e. V., Grant #2676) as well as a travelling grant provided by the Karlsruhe House of Young Scientists (KHYS).
- Colin B, Mandrand B (1999) Vanne statique à congélation, et enceinte de traitement contrôlée par au moins une telle vanne. France Patent 01(09):1999Google Scholar
- Kabei N, Kosuda M, Kagamibuchi H, Tashiro R, Mizuno H, Ueda Y, Tsuchiya K (1997) A thermal-expansion-type microactuator with paraffin as the expansive material (basic performance of a prototype linear actuator). JSME Int J Ser C Mech Syst Mach Elem Manuf 40(4):736–742Google Scholar
- Lee CC, Sui GD, Elizarov A, Shu CYJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR (2005) Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science 310(5755):1793–1796. doi: 10.1126/science.1118919 CrossRefGoogle Scholar
- Neumann C, Voigt A, Rapp BE (2011) A large scale thermal microfluidic valve platform. In: Landers JP, Herr A, Juncker D, Pamme N, Bienvenue J (eds) The 15th international conference on miniaturized systems for chemistry and life sciences (μTAS 2011), Seattle, USA, 2011. pp 428–430Google Scholar
- Rapp BE, Duttenhofer T, Laenge K (2010) 20/100/400-channel chemically inert, reversibel parallel microfluidic connector as generic chip-to-world interface. In: Verpoorte S, Andersson-Swahn H, Emnéus J, Pamme N (eds) The 14th international conference on miniaturized systems for chemistry and life sciences (μTAS 2010), Groningen, The Netherlands, 2010. pp 1121–1123Google Scholar
- Takagi Y, Kojima Y, Mitani K (1995) Apparatus for and method of controlling the opening and closing of channel for liquid. Jpn Patent 05(04):1995Google Scholar