Microfluidics and Nanofluidics

, Volume 13, Issue 3, pp 399–409 | Cite as

Microfluidic motion for a direct investigation of solvent interactions with PDMS microchannels

  • Monica BiancoEmail author
  • Ilenia Viola
  • Miriam Cezza
  • Francesca Pietracaprina
  • Giuseppe Gigli
  • Rosaria Rinaldi
  • Valentina Arima
Research Paper


Solid surface/liquid interactions play an important role in microfluidics and particularly in manipulation of films, drops and bubbles, a basic requirement for a number of lab-on-chip applications. The behavior of solvents in coated microchannels is difficult to be predicted considering theories; therefore, experimental methods able to estimate the properties at the interface in real time and during the operational regime are amenable. Here, we propose to use an experimental setup to evaluate the effective dynamics of solvents inside PDMS microchannels. The influence of the solvent properties as well as of the channel wall’s wettability on the fluid movements was evaluated. Modification of the channel properties was achieved by introducing Teflon coatings that allow producing stable hydrophobic microchannel walls. The results were fitted according to Washburn-type power-law and compared with theoretical calculations of the parameter β that expresses the dependence of capillary dynamics on surface tension γ, liquid viscosity η, contact angles θ and the hydraulic radius R H. A comparison between the calculated and the experimental values reveled that parameters other than the contemplated ones influenced the measurements. The main parameter that affects the flow of solvents such as water, methanol ethanol, dimethylformamide, acetonitrile and acetone was found to be the γ/η ratio. Considering these results, the investigation tool described here is believed to be promising to predict the dynamics of common organic solvents inside integrated functional fluidic devices and to accurately control solvent flow, particularly in capillary-driven pumpless systems, a basic requirement for widening the application range of PDMS lab-on-chip devices.


Microfluidics PDMS microchannels Teflon coating Washburn power law 



The authors acknowledge the EU project “ROC”, grant agreement no. 213803 for financial support and Stefania D’Amone and Elisabetta Perrone for the technical support.


  1. Amarouchene Y, Bonn D, Meunier J, Kellay H (2001) Inhibition of the finite-time singularity during droplet fission of a polymeric fluid. Phys Rev Lett 86:3558–3561CrossRefGoogle Scholar
  2. Arima V, Bianco M, Zacheo A, Zizzari A, Perrone E, Marra L, Rinaldi R (2011) Fluoropolymers coatings on PDMS for retarding swelling in toluene. Thin Solid Films 520:2293–2300CrossRefGoogle Scholar
  3. Bain CD (2001) Motion of liquids on surfaces. Chem Phys Chem 2:580–582CrossRefGoogle Scholar
  4. Bart SF, Tavrow LS, Mehregany M, Lang JH (1990) Microfabricated electrohydrodynamic pumps. Sens Actuators A21:193–197CrossRefGoogle Scholar
  5. Cheng ZY, Gross S, Su J, Zhang QM (1999) Pressure–temperature study of dielectric relaxation of a polyurethane elastomer. J Polymer Sci B Polymer Phys 37:983–990CrossRefGoogle Scholar
  6. Darhuber AA, Troian SM (2001) Dynamics of capillary spreading along hydrophilic microstripes. Phys Rev E 64:031603CrossRefGoogle Scholar
  7. Darhuber AA, Troian SM (2005) Principles of microfluidic actuation by modulation of surface stresses. Annu Rev Fluid Mech 37:425–455MathSciNetCrossRefGoogle Scholar
  8. Darhuber AA, Valentino JP, Davis JM, Troian SM, Wagner S (2003) Microfluidic actuation by modulation of surface stresses. Appl Phys Lett 82:657–659CrossRefGoogle Scholar
  9. Delamarche E, Bernard A, Schmid H, Bietsch A, Michel B, Biebuyck H (1998) Microfluidic networks for chemical patterning of substrate: design and application to bioassays. J Am Chem Soc 120:500–508CrossRefGoogle Scholar
  10. Duffy DC, Gillis HL, Lin J, Sheppard NF, Kellogg GJ (1999) Microfabricated centrifugal microfluidic systems: characterization and multiple enzymatic assays. Anal Chem 71:4669–4678CrossRefGoogle Scholar
  11. Fritz JL, Owen MJ (1995) Hydrophobic recovery of plasma-treated polydimethylsiloxane. J Adhesion 54(1–2):33–45CrossRefGoogle Scholar
  12. Gervais L, Delamarche E (2009) Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates. Lab Chip 9:3330–3337CrossRefGoogle Scholar
  13. Ichikawa N, Hosokawa K, Maeda R (2004) Interface motion of capillary-driven flow in rectangular microchannel. J Colloid Interface Sci 280:155–164CrossRefGoogle Scholar
  14. Jang J, Lee SS (2000) Theoretical and experimental study of MHD (magnetohydrodynamic) micropump. Sens Actuators A80:84–89CrossRefGoogle Scholar
  15. Jones TB, Gunji M, Washizu M, Feldman MJ (2001) Dielectrophoretic liquid actuation and nanodroplet formation. J Appl Phys 89:1441–1448CrossRefGoogle Scholar
  16. Jones TB, Wang KL, Yao DJ (2004) Frequency-dependent electromechanics of aqueous liquids: electrowetting and dielectrophoresis. Langmuir 20:2813–2818CrossRefGoogle Scholar
  17. Kim J, Chaudhury MK, Owen MJ, Orbeck T (2001) The mechanisms of hydrophobic recovery of polydimethylsiloxane elastomers exposed to partial electrical discharges. J Colloid Interface Sci 244:200–207CrossRefGoogle Scholar
  18. Kimmich R (2002) Strange kinetics, porous media, and NMR. Chem Phys 284(1–2):253–285CrossRefGoogle Scholar
  19. Kornev KG, Neimark AV (2003) Modeling of spontaneous penetration of viscoelastic fluids and biofluids into capillaries. J Colloid Interface Sci 262:253–262CrossRefGoogle Scholar
  20. Lee J, Kim CJJ (2000) Surface-tension-driven microactuation based on continuous electrowetting. Microelectromech Syst 9:171–180zbMATHCrossRefGoogle Scholar
  21. Lee JN, Park C, Whitesides GM (2003) Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal Chem 75:6544–6554CrossRefGoogle Scholar
  22. Park SJ, Liechti KM (2003) Rate-dependent large strain behavior of a structural adhesive. Mech Time Depend Mater 7:143–164CrossRefGoogle Scholar
  23. Pfahler J, Harley J, Bau H, Zemel J (1990) Liquid transport in micron and submicron channels. Sens Actuators A22:431–434Google Scholar
  24. Pollack MG, Fair RB, Shenderov AD (2000) Modification of GaN Schottky barrier interfaces probed by ballistic-electron-emission microscopy and spectroscopy. Appl Phys Lett 77:1725–1726CrossRefGoogle Scholar
  25. Roth J, Albrecht V, Nitschke M, Bellmann C, Simon F, Zschoche S, Michel S, Luhmann C, Grundke K, Voit B (2008) Surface functionalization of silicone rubber for permanent adhesion improvement. Langmuir 24:1260–1261Google Scholar
  26. Squires TM, Quake SR (2005) Microfluidics: fluid physics at the nanoliter scale. Rev Mod Phys 77:977–1026CrossRefGoogle Scholar
  27. Stone HA, Stroock AD, Adjari A (2004) Engineering flows in small devices: microfluidics toward a lab-on-a-chip. Annu Rev Fluid Mech 36:381–411Google Scholar
  28. Viola I, Pisignano D, Cingolani R, Gigli G (2005) Microfluidic motion for a direct investigation of the structural dynamics of glass-forming liquids. Anal Chem 77(2):591–595CrossRefGoogle Scholar
  29. Viola I, Ciccarella G, Metrangolo P, Resnati G, Cingolani R, Gigli G (2007) Microfluidic behaviour of perfluoropolyether fluids in poly(dimethylsiloxane) micro-channels. J Fluorine Chem 128:1335–1339CrossRefGoogle Scholar
  30. Williams RL, Wilson DJ, Rhodes NP (2004) Stability of plasma-treated silicone rubber and its influence on the interfacial aspects of blood compatibility. Biomaterials 25:4659–4673CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Monica Bianco
    • 1
    Email author
  • Ilenia Viola
    • 1
    • 2
  • Miriam Cezza
    • 1
  • Francesca Pietracaprina
    • 1
  • Giuseppe Gigli
    • 1
    • 2
    • 3
  • Rosaria Rinaldi
    • 1
  • Valentina Arima
    • 1
  1. 1.National Nanotechnology Laboratory, CNR-Istituto Nanoscienze, U.O.S. Lecce–Distretto Tecnologico ISUFIUniversità del SalentoLecceItaly
  2. 2.National Nanotechnology Laboratory, CNR-Istituto Nanoscienze, c/o Dipartimento di FisicaUniversità La SapienzaRomeItaly
  3. 3.Dip. Ingegneria InnovazioneUniversità del SalentoLecceItaly

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