Microfluidics and Nanofluidics

, Volume 10, Issue 4, pp 785–791 | Cite as

A novel polymer microneedle fabrication process for active fluidic delivery

  • Bernardo Cordovez
  • Aram J. Chung
  • Michael Mak
  • David Erickson
Research Paper

Abstract

In this article, we explore a new fabrication process for a flexible, all polymer, active fluidic delivery system, incorporating a fusion of laser micromachining and microfabrication techniques as well as rapid prototyping technology. Here, we show selective fluidic delivery from isolated microchannels through an electrochemically driven pumping reaction, demonstrate the dispensing of dose volumes up to 5.5 μl, and evaluate the device’s performance in terms of its delivery speed and ejection efficiency. Finally, we move this work toward an implantable microfluidic drug delivery device by investigating the device’s biocompatibility through a statistical approach that overviews the viability of bovine aortic endothelial cells on polyimide and silicon substrates.

Keywords

Implantable drug delivery Microfluidics Polyimide Rapid prototyping Electrochemistry 

Supplementary material

10404_2010_709_MOESM1_ESM.pdf (272 kb)
Supplementary material 1 (PDF 272 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Bernardo Cordovez
    • 1
  • Aram J. Chung
    • 1
  • Michael Mak
    • 2
  • David Erickson
    • 1
  1. 1.Sibley School of Mechanical and Aerospace EngineeringCornell UniversityIthacaUSA
  2. 2.Department of Biomedical EngineeringCornell UniversityIthacaUSA

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