Microfluidics and Nanofluidics

, Volume 10, Issue 4, pp 785–791 | Cite as

A novel polymer microneedle fabrication process for active fluidic delivery

  • Bernardo Cordovez
  • Aram J. Chung
  • Michael Mak
  • David Erickson
Research Paper


In this article, we explore a new fabrication process for a flexible, all polymer, active fluidic delivery system, incorporating a fusion of laser micromachining and microfabrication techniques as well as rapid prototyping technology. Here, we show selective fluidic delivery from isolated microchannels through an electrochemically driven pumping reaction, demonstrate the dispensing of dose volumes up to 5.5 μl, and evaluate the device’s performance in terms of its delivery speed and ejection efficiency. Finally, we move this work toward an implantable microfluidic drug delivery device by investigating the device’s biocompatibility through a statistical approach that overviews the viability of bovine aortic endothelial cells on polyimide and silicon substrates.


Implantable drug delivery Microfluidics Polyimide Rapid prototyping Electrochemistry 



The authors would like to thank Michael Kalontarov for helpful discussions, Prof. Hod Lipson for access to the 3-D Acrylic Printer and Dr. Mehmet Ozgur at the MEMS and Nanotechnology Exchange for the laser etch process. This work was supported by the Defense Advanced Research Projects Agency Defense Sciences Office under the Hybrid Insect MEMS “HI-MEMS” program through the Boyce Thompson Institute for Plant Research. Distribution unlimited. Portions of this work were also supported by the Office of Naval Research under grant “Autonomous Microfluidic Devices for Battlefield Health Assessment and Treatment” which has award number N000141010115. The facilities used for this research include Nanoscale Science & Technology Facility (CNF), Nanobiotechnology Center (NBTC) at Cornell University.

Supplementary material

10404_2010_709_MOESM1_ESM.pdf (272 kb)
Supplementary material 1 (PDF 272 kb)


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Bernardo Cordovez
    • 1
  • Aram J. Chung
    • 1
  • Michael Mak
    • 2
  • David Erickson
    • 1
  1. 1.Sibley School of Mechanical and Aerospace EngineeringCornell UniversityIthacaUSA
  2. 2.Department of Biomedical EngineeringCornell UniversityIthacaUSA

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