Microfluidics and Nanofluidics

, Volume 9, Issue 6, pp 1165–1174 | Cite as

Mixing speed-controlled gold nanoparticle synthesis with pulsed mixing microfluidic system

  • Koji SuganoEmail author
  • Yuki Uchida
  • Osamu Ichihashi
  • Hideo Yamada
  • Toshiyuki Tsuchiya
  • Osamu Tabata
Research Paper


Gold nanoparticles with diameters of a few tens of nanometer and a narrow size distribution were synthesized using a pulsed mixing method with a microfluidic system which consists of a Y-shaped mixing microchannel and two piezoelectric valveless micropumps. This mixing method enables control of the mixing speed of gold salts and reducing agent by changing the switching frequency of the micropumps, which was our focus to improve the particle size distribution, which is an essential parameter in gold nanoparticle synthesis. In the proposed method, the mixing time was inversely proportional to the switching frequency and the minimum mixing time was 95 ms at a switching frequency of 200 Hz. During synthesis experiments, the mean diameter of the synthesized gold nanoparticles was found to increase, and the coefficient of variation of particle size was found to decrease with decreasing mixing time. We successfully improved the coefficient of variation to less than 10% for a mean diameter of around 40 nm.


Gold nanoparticle Mixing speed Pulsed mixing Microfluidic device Micropump 



This work was conducted in Kyoto-Advanced Nanotechnology Network, and supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. This work was also supported by Grant-in-Aid for Young Scientists B (No.18710078). The authors are grateful to Sadamu Kinoshita for the SEM observations.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Koji Sugano
    • 1
    Email author
  • Yuki Uchida
    • 1
  • Osamu Ichihashi
    • 1
  • Hideo Yamada
    • 1
  • Toshiyuki Tsuchiya
    • 1
  • Osamu Tabata
    • 1
  1. 1.Department of Micro Engineering, Graduate School of EngineeringKyoto UniversityKyotoJapan

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