Microfluidics and Nanofluidics

, Volume 8, Issue 3, pp 313–327 | Cite as

Augmented surface adsorption characteristics by employing patterned microfluidic substrates in conjunction with transverse electric fields

Research Paper

Abstract

The present study aims to theoretically demonstrate that the net rate of surface adsorption in a combined pressure driven and electrokinetically operated microfluidic arrangement may be considerably augmented with the application of transverse electric fields across the patterned walls of the flow channel, within the constraints of realistic biochemical reactions at chosen surface sites. Based on an approximate fully developed velocity profile that utilises the generation of an additional favourable axial pressure gradient (obtained as a combined consequence of the transverse and axial fields as well as the surface patterning effects), solutions of the species conservation equation are obtained, consistent with a combined advection–diffusion transport and second order reaction kinetics occurring at surface sites located on the microchannel walls. Different combinations of the electric fields and pattern angles are investigated, so as to obtain a physical basis governing their optimal combinations that are likely to result in the fastest possible net adsorption rates, within the practicalities of the chosen configuration. Some important considerations on the practical realisability of the designed configuration are also discussed.

Keywords

Micro-reaction Surface adsorption Electrical double layer Microchannel Patterning 

References

  1. Ajdari A (1995) Electro-osmosis on inhomogeneously charged surfaces. Phys Rev Lett 75:755–759CrossRefGoogle Scholar
  2. Ajdari A (1996) Generation of transverse fluid currents and forces by an electric field: electro-osmosis on charge-modulated and undulated surfaces. Phys Rev E 53:4996–5005CrossRefGoogle Scholar
  3. Ajdari A (2002) Transverse electrokinetic and microfluidic effects in micropatterned channels: Lubrication analysis for slab geometries. Phys Rev E 65:1–9Google Scholar
  4. Barker SLR, Tarlov MJ, Canavan H, Hickman JJ, Locascio LE (2000) Plastic microfluidic devices modified with polyelectrolyte multilayers. Anal Chem 72:4899–4903CrossRefGoogle Scholar
  5. Barrett LM, Skulan AJ, Singh AK, Cummings EB, Fiechtner GJ (2005) Dielectrophoretic manipulation of particles and cells using insulating ridges in faceted prism microchannels. Anal Chem 77:6798–6804CrossRefGoogle Scholar
  6. Brunet E, Ajdari A (2006) Thin double layer approximation to describe streaming current fields in complex geometries: analytical framework and applications to microfluidics. Phys Rev E 73:1–15Google Scholar
  7. Das S, Chakraborty S (2006) Augmentation of macromolecular adsorption rates through transverse electric fields generated across patterned walls of a microfluidic channel. J Appl Phys 100:1–8Google Scholar
  8. Das S, Das T, Chakraborty S (2006) Modeling of coupled momentum, heat and solute transport during DNA hybridization in a microchannel in the presence of electro-osmotic effects and axial pressure gradients. Microfluid Nanofluid 2:37–49CrossRefGoogle Scholar
  9. Das S, Subramanian K, Chakraborty S (2007) Analytical investigations on the effects of substrate kinetics on macromolecular transport and hybridization through microfluidic channels. Coll Surf B Bioint 58:203–217CrossRefGoogle Scholar
  10. Gitlin I, Stroock AD, Whitesides GM, Ajdari A (2003) Pumping based on transverse electrokinetic effects. Appl Phys Lett 83:1486–1488CrossRefGoogle Scholar
  11. Hahm J, Balasubramanian A, Beskok A (2007) Flow and species transport control in grooved microchannels using local electrokinetic forces. Phys Fluid 19:1–9Google Scholar
  12. Hau WLW, Trau DW, Sucher NJ, Wong M, Zohar Y (2003) Surface-chemistry technology for microfluidics. J Micromech Microeng 13:272–278CrossRefGoogle Scholar
  13. Hunter RJ (1981) Zeta potential in colloid science: principles and applications. Academic Press, LondonGoogle Scholar
  14. Hunter RJ (1991) Foundations of colloid science. Oxford University Press, New YorkGoogle Scholar
  15. Kassegne SK, Resse H, Hodko D, Yang JM, Sarkar K, Smolko D, Swanson P, Raymond DE, Heller MJ, Madou MJ (2003) Numerical modeling of transport and accumulation of DNA on electronically active biochips. Sens Act B 94:81–98CrossRefGoogle Scholar
  16. Kim JH, Marafie A, Jia X, Zoval JV, Madou MJ (2006a) Characterization of DNA hybridization kinetics in a microfluidic flow channel. Sens Act B 113:281–289CrossRefGoogle Scholar
  17. Kim D, Tamiya E, Kwon Y (2006b) Development of a novel DNA detection system for real-time detection of DNA hybridization. Curr Appl Phys 6:669–674CrossRefGoogle Scholar
  18. Kim J, Voelkerding KV, Gale BK (2006c) Patterning of a nanoporous membrane for multi-sample DNA extraction. J Micromech Microeng 16:33–39CrossRefGoogle Scholar
  19. Kuksenok O, Balazs AC (2004) Structures formation in binary fluids driven through patterned microchannels: effect of hydrodynamics and arrangement of surface patterns. Phys D 198:319–332MATHCrossRefGoogle Scholar
  20. Kuksenok O, Yeomans JM, Balazs AC (2002) Using patterned substrates to promote mixing in microchannels. Phys Rev E 65:1–8Google Scholar
  21. Kuksenok O, Jasnow D, Yeomans JM, Balazs AC (2003) Periodic droplet formation in chemically patterned microchannels. Phys Rev Lett 91:1–4Google Scholar
  22. Kusumaatmaja H, Pooley CM, Girardo S, Pisignano D, Yeomans JM (2008) Capillary filling in patterned channels. Phys Rev E 77:1–4Google Scholar
  23. Lee LM, Hau WLW, Lee YK, Zohar Y (2006) In-plane vortex flow in microchannels generated by electroosmosis with patterned surface charge. J Micromech Microeng 16:17–26CrossRefGoogle Scholar
  24. Li Y, Wong GCL, Caine E, Hu EL, Safinya CR (1998) Structural studies of DNA-cationic lipid complexes confined in lithographically patterned microchannel arrays. Int J Thermophys 19:1165–1174CrossRefGoogle Scholar
  25. Lin W (2008) A passive grooved micromixer generating enhanced transverse rotations for microfluids. Chem Eng Technol 31:1210–1215CrossRefGoogle Scholar
  26. Pluen A, Netti PA, Jain RK, Berk DA (1999) Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys J 77:542–552CrossRefGoogle Scholar
  27. Stone HA, Strook AD, Ajdari A (2004) Engineering flows in small devices. Annu Rev Fluid Mech 36:381–411CrossRefGoogle Scholar
  28. Stroock AD, Weck M, Chiu DT, Huck WTS, Kenis PJA, Ismagilov RA, Whitesides GM (2000) Patterning electro-osmotic flow with patterned surface charge. Phys Rev Lett 84:3314–3317CrossRefGoogle Scholar
  29. Stroock AD, Dertinger K, Whitesides GM, Ajdari A (2002a) Patterning flows using grooved surfaces. Anal Chem 74:5306–5312CrossRefGoogle Scholar
  30. Stroock AD, Dertinger SKW, Ajdari A, Mezic I, Stone HA, Whitesides GM (2002b) Chaotic mixer for microchannels. Nature 295:647–651Google Scholar
  31. Wang H, Iovenitti P, Harvey E, Masood S (2003) Numerical investigation of mixing in microchannels with patterned grooves. J Micromech Microeng 13:801–808CrossRefGoogle Scholar
  32. Zeng J, Almadidy A, Watterson J, Krull UJ (2002) Interfacial hybridization kinetics of oligonucleotides immobilized onto fused silica surfaces. Sens Act B 90:68–75CrossRefGoogle Scholar
  33. Zholkovskij EK, Masliyah JH (2004) Hydrodynamic dispersion due to combined pressure-driven and electroosmotic flow through microchannels with a thin double layer. Anal Chem 76:2708–2718CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringIndian Institute of TechnologyKharagpurIndia

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