Microfluidics and Nanofluidics

, Volume 6, Issue 6, pp 847–852

Acoustically induced bubbles in a microfluidic channel for mixing enhancement

  • S. S. Wang
  • Z. J. Jiao
  • X. Y. Huang
  • C. Yang
  • N. T. Nguyen
Short Communication

Abstract

Due to small dimensions and low fluid velocity, mixing in microfluidic systems is usually poor. In this study, we report a method of enhancing microfluidic mixing using acoustically induced gas bubbles. The effect of applied frequency on mixing was investigated over the range 0.5–10 kHz. Under either low frequency 0.5 kHz or high frequency 10 kHz, no noticeable improvement in the present mixer was observed. However, a significant increase in the mixing efficiency was achieved within a window of the frequencies between 1.0 and 5.0 kHz. It was found in our present microfluidic structure, single (or multi-) bubble(s) could be acoustically generated under the frequency ranging from 1.0 to 5.0 kHz by a piezoelectric disc. The interaction between bubble and acoustic field causes bubble oscillation which in turn could disturb local flow field to result in mixing enhancement.

Keywords

Microfluidics Mixing Acoustic cavitation 

References

  1. Bau HH, Zhong J, Yi M (2001) A minute magneto hydro dynamic (MHD) mixer. Sens Actuators B 79:207–215CrossRefGoogle Scholar
  2. Beebe D, Mensing GA, Walker GM (2002) Physics and applications of microfluidics in biology. Ann Rev Biomed Eng 4:261–286CrossRefGoogle Scholar
  3. Biddiss E, Erickson D, Li D (2004) Heterogeneous surface charge enhanced micromixing for electrokinetic flows. Anal Chem 76:3208–3213CrossRefGoogle Scholar
  4. El Moctar AO, Aubry N, Batton J (2003) Electro hydrodynamic micro-fluidic mixer. Lab Chip 3:273–280CrossRefGoogle Scholar
  5. Erickson D, Li D (2004) Integrated microfluidic devices. Anal Chim Acta 507:11–26CrossRefGoogle Scholar
  6. Glasgow I, Aubry N (2003) Enhancement of microfluidic mixing using time pulsing. Lab Chip 3:114–120CrossRefGoogle Scholar
  7. He B, Burke BJ, Zhang X, Zhang R, Reginer FE (2001) A picoliter-volume mixer for microfluidic analytical systems. Anal Chem 73:1942–1947CrossRefGoogle Scholar
  8. Hessel V, Loewe H, Schoenfield F (2005) Micromixers-a review on passive and active mixing principles. Chem Eng Sci 60:2479–2501CrossRefGoogle Scholar
  9. Herbert E, Balibar S, Caupin F (2006) Cavitation pressure in water. Phys Rev E 74:041603CrossRefGoogle Scholar
  10. Liau A, Karnik R, Majumdar A, Cate JD (2005) Mixing crowded biological solutions in microfluidics. Anal Chem 77:7618–7625CrossRefGoogle Scholar
  11. Liu RH, Stremler M, Sharp KV, Olsen MG, Santiago JG, Adrian RJ, Aref H, Beebe DJ (2000) J Microelectromech Syst 9:190–197CrossRefGoogle Scholar
  12. Liu RH, Yang J, Pindera MZ, Athavale M, Grodzinski P (2002) Bubble-induced acoustic micromixing. Lab chip 2:151–157CrossRefGoogle Scholar
  13. Luo C, Huang XY, Nguyen NT (2007) Generation of shock free pressure waves in shaped resonators by boundary driving. J Acoustic Soc Am 121:2515–2525CrossRefGoogle Scholar
  14. Madan S, Sameer I (2005) Method and apparatus for acoustic suppression of cavitation. US Patent 6846365Google Scholar
  15. Nguyen NT, Wu ZG (2005) Micromixers—a review. J Micromech Microeng 15:R1–R16CrossRefGoogle Scholar
  16. Oddy MH, Santiago JG, Mikkelsen JC (2001) Electrokinetic instability micromixing. Anal Chem 73:5822–5832CrossRefGoogle Scholar
  17. Song H, Li HW, Munson MS, van Ha TG, Ismagilov RF (2006) On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Anal Chem 78:4839–4849CrossRefGoogle Scholar
  18. Stroock AD, Dertinger SK, Ajdari A, Mezic I, Stone HA, Whitesides GM (2002) Chaotic mixer for microchannels. Science 295:647–651CrossRefGoogle Scholar
  19. Tudos AJ, Besselink GAJ, Schasfoort RBM (2001) Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry. Lab Chip 1:83–85CrossRefGoogle Scholar
  20. Yang Z, Matsumoto S, Goto H, Matsumoto M, Maeda R (2001) Ultrasonic micromixer for microfluidic systems. Sens Actuators A 93:266–272CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • S. S. Wang
    • 1
  • Z. J. Jiao
    • 1
  • X. Y. Huang
    • 1
  • C. Yang
    • 1
  • N. T. Nguyen
    • 1
  1. 1.School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

Personalised recommendations