Journal of Medical Ultrasonics

, Volume 46, Issue 2, pp 217–222 | Cite as

Clinical application of ultrasound-guided percutaneous microwave ablation in the treatment of T1aN0M0 stage renal carcinoma

  • Guoqing Sui
  • Qiang Luo
  • Jiarui Du
  • Dengke Teng
  • Hui WangEmail author
Original Article



Evaluation of clinical application of ultrasound-guided percutaneous microwave ablation treatment for T1a renal carcinoma.


Analysis of the clinical data from 31 patients with T1aN0M0 stage renal carcinoma who underwent ultrasound-guided percutaneous microwave ablation in the Department of Ultrasound of China-Japan Union Hospital of Jilin University between March 2010 and June 2014.


All of the 31 patients were treated with ablation only once: 96.8% (30/31) of patients had no local recurrence or distant metastasis after ablation. One (3.2%) patient had local tumor recurrence 6 months after surgery and underwent a second microwave ablation. According to the results of 2 years of follow-up re-examinations, no further recurrence or distant metastasis was found. Moreover, 90.3% (28/31) of the patients had no complications with normal ranges of preoperative and postoperative serum creatinine and urea nitrogen levels. Complications were found in 9.7% (3/31) of the patients: one case of transient hematuria, one case of perirenal hematoma, and one case of cholecystitis; the symptoms were resolved with symptomatic treatment.


Ultrasound-guided percutaneous microwave ablation is a safe and effective micro-invasive therapy for T1a renal cancer patients.


Ultrasound-guided Microwave Ablation Kidney cancer 



This study was funded by the Finance Department of Jilin Province (No. SCZSY201618).

Compliance with ethical standards

Ethical statements

This study was conducted in accordance with the declaration of Helsinki. This study was conducted with approval from the Ethics Committee of Jilin University. Written informed consent was obtained from all participants.

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.CrossRefGoogle Scholar
  2. 2.
    Ridge CA, Pua BB, Madoff DC. Epidemiology and staging of renal cell carcinoma. Semin Intervent Radiol. 2014;31:3–8.CrossRefGoogle Scholar
  3. 3.
    Hancock SB, Georgiades CS. Kidney Cancer. Cancer J. 2016;22:387–92.CrossRefGoogle Scholar
  4. 4.
    Dunnick NR. Renal cell carcinoma: staging and surveillance. AbdomRadiol (NY). 2016;41:1079–85.Google Scholar
  5. 5.
    Pham D, Kron T, Bressel M, et al. Image guidance and stabilization for stereotactic ablative body radiation therapy (SABR) treatment of primary kidney cancer. Pract Radiat Oncol. 2015;5:e597–605.CrossRefGoogle Scholar
  6. 6.
    Ghandour RA, Danzig MR, McKiernan JM. Renal cell carcinoma: risks and benefits of nephron-sparing surgery for T1 tumors. Adv Chronic Kidney Dis. 2015;22:258–65.CrossRefGoogle Scholar
  7. 7.
    Sato T, Iguchi T, Hiraki T, et al. Radiofrequency ablation of pulmonary metastases from sarcoma: single-center retrospective evaluation of 46 patients. Jpn J Radiol. 2017;35:61–7.CrossRefGoogle Scholar
  8. 8.
    Georgiades C, Rodriguez R. Renal tumor ablation. Tech Vasc Interv Radiol. 2013;16:230–8.CrossRefGoogle Scholar
  9. 9.
    Vetterlein MW, Jindal T, Becker A, et al. Small renal masses in the elderly: contemporary treatment approaches and comparative oncological outcomes of nonsurgical and surgical strategies. Investig Clin Urol. 2016;57:231–9.CrossRefGoogle Scholar
  10. 10.
    Lin Y, Liang P, Yu XL, et al. Percutaneous microwave ablation of renal cell carcinoma is safe in patients with a solitary kidney. Urology. 2014;83:357–63.CrossRefGoogle Scholar
  11. 11.
    Lin Y, Liang P, Yu XL, et al. Percutaneous microwave ablation of renal cell carcinoma is safe in patients with renal dysfunction. Int J Hyperthermia. 2016;15:1–6.Google Scholar
  12. 12.
    Zhang M, Liang P, Cheng ZG, et al. Efficacy and safety of artificial ascites in assisting percutaneous microwave ablation of hepatic tumours adjacent to the gastrointestinal tract. Int J Hyperthermia. 2014;30:134–41.CrossRefGoogle Scholar
  13. 13.
    Ahmed M. Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update: supplement to the consensus document. J Vasc Interv Radiol. 2014;25:1706–8.CrossRefGoogle Scholar
  14. 14.
    Crepel M, Jeldres C, Perrotte P, et al. Nephron-sparing surgery is equally effective to radical nephrectomy for T1bN0M0 renal cell carcinoma: a population-based assessment. Urology. 2010;75:271–5.CrossRefGoogle Scholar
  15. 15.
    Hernández JI, Cepeda MF, Valdes F, et al. Microwave ablation: state-of-the-art review. Onco Targets Ther. 2015;8:1627–32.Google Scholar
  16. 16.
    Vroomen LGPH, Petre EN, Cornelis FH, et al. Irreversible electroporation and thermal ablation of tumors in the liver, lung, kidney and bone: what are the differences? Diagn Interv Imaging. 2017;98:609–17.CrossRefGoogle Scholar
  17. 17.
    Isfort P, Penzkofer T, Mahnken AH. Efficacy of antegrade pyeloperfusion to protect the renal pelvis in kidney microwave ablation using an in vivo swine model. Invest Radiol. 2013;48:863–8.CrossRefGoogle Scholar
  18. 18.
    Saeednejad Zanjani L, Madjd Z, Abolhasani M, et al. Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma. Exp Mol Pathol. 2017;103:218–28.CrossRefGoogle Scholar
  19. 19.
    Zhao X, Wang W, Zhang S, et al. Improved outcome of percutaneous radiofrequency ablation in renal cell carcinoma: a retrospective study of intraoperative contrast-enhanced ultrasonography in 73 patients. Abdom Imaging. 2012;37:885–91.CrossRefGoogle Scholar
  20. 20.
    Carrafiello G, Mangini M, Fontana F, et al. Single-antenna microwave ablation under contrast-enhanced ultrasound guidance for treatment of small renal cell carcinoma: preliminary experience. Cardiovasc Intervent Radiol. 2010;33:367–74.CrossRefGoogle Scholar

Copyright information

© The Japan Society of Ultrasonics in Medicine 2018

Authors and Affiliations

  1. 1.Department of UltrasoundChina-Japan Union Hospital of Jilin UniversityChangchunChina

Personalised recommendations