Preoperative diagnosis of a giant cell tumor of soft tissue arising from the breast by ultrasound-guided core needle biopsy
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Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. Herein, we report a case of a 45-year-old woman with a 5-cm mass in her left breast. Ultrasonography revealed a mainly well-circumscribed mass that contained a cystic lesion. Magnetic resonance imaging showed a fibrous capsule-covered mass that contained a high-intensity area, suggesting hemorrhaging. Ultrasound-guided core needle biopsy (CNB) revealed mononuclear histiocytic cells with a round shape or spindled appearance that was mixed with multinucleated giant cells. Immunohistochemical analysis revealed CD68-positive staining in the mononuclear and giant cells but negative staining for pancytokeratin. Preoperatively, the tumor was highly suspected of being GCT-ST. Histopathological results after a left mastectomy showed similar findings to CNB. The final diagnosis was GCT-ST in the breast. To the best of our knowledge, this is the first case report of a GCT-ST arising in the breast diagnosed by ultrasound-guided CNB.
KeywordsGiant cell tumor Giant cell tumor of soft tissue in breast Breast tumor
The authors would like to thank Dr. Bryan J. Mathis of the Medical English Communication Center (University of Tsukuba, Japan) for native English editing of this manuscript.
Compliance with ethical standards
Conflict of interest
Aya Sawa, Tatsuhiko Ikeda, Emika Ichioka, Yukiko Tsushima, Akiko Iguchi, Hiroko Bando, Yuzuru Kondo, and Hisato Hara declare that they have no conflicts of interest.
All procedures followed were in accordance with the ethical standards of the responsible committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients prior to inclusion in the study.
- 9.Fletcher CDM, Bridge JA, Hogendoorn PCW, et al. WHO classification of tumors of soft tissue and bone. 4th ed. Lyon: International agency for research on cancer; 2013. p. 106.Google Scholar