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Journal of Medical Ultrasonics

, Volume 46, Issue 2, pp 257–261 | Cite as

Preoperative diagnosis of a giant cell tumor of soft tissue arising from the breast by ultrasound-guided core needle biopsy

  • Aya Sawa
  • Tatsuhiko IkedaEmail author
  • Emika Ichioka
  • Yukiko Tsushima
  • Akiko Iguchi-Manaka
  • Hiroko Bando
  • Yuzuru Kondo
  • Hisato Hara
Case Report
  • 93 Downloads

Abstract

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. Herein, we report a case of a 45-year-old woman with a 5-cm mass in her left breast. Ultrasonography revealed a mainly well-circumscribed mass that contained a cystic lesion. Magnetic resonance imaging showed a fibrous capsule-covered mass that contained a high-intensity area, suggesting hemorrhaging. Ultrasound-guided core needle biopsy (CNB) revealed mononuclear histiocytic cells with a round shape or spindled appearance that was mixed with multinucleated giant cells. Immunohistochemical analysis revealed CD68-positive staining in the mononuclear and giant cells but negative staining for pancytokeratin. Preoperatively, the tumor was highly suspected of being GCT-ST. Histopathological results after a left mastectomy showed similar findings to CNB. The final diagnosis was GCT-ST in the breast. To the best of our knowledge, this is the first case report of a GCT-ST arising in the breast diagnosed by ultrasound-guided CNB.

Keywords

Giant cell tumor Giant cell tumor of soft tissue in breast Breast tumor 

Notes

Acknowledgements

The authors would like to thank Dr. Bryan J. Mathis of the Medical English Communication Center (University of Tsukuba, Japan) for native English editing of this manuscript.

Compliance with ethical standards

Conflict of interest

Aya Sawa, Tatsuhiko Ikeda, Emika Ichioka, Yukiko Tsushima, Akiko Iguchi, Hiroko Bando, Yuzuru Kondo, and Hisato Hara declare that they have no conflicts of interest.

Ethical statement

All procedures followed were in accordance with the ethical standards of the responsible committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients prior to inclusion in the study.

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Copyright information

© The Japan Society of Ultrasonics in Medicine 2018

Authors and Affiliations

  • Aya Sawa
    • 1
  • Tatsuhiko Ikeda
    • 1
    • 2
    Email author
  • Emika Ichioka
    • 2
  • Yukiko Tsushima
    • 2
  • Akiko Iguchi-Manaka
    • 2
  • Hiroko Bando
    • 2
  • Yuzuru Kondo
    • 3
  • Hisato Hara
    • 2
  1. 1.Department of Breast-Thyroid-Endocrine Surgery, Tsukuba University HospitalUniversity of TsukubaTsukubaJapan
  2. 2.Department of Breast and Endocrine Surgery, Faculty of MedicineUniversity of TsukubaIbarakiJapan
  3. 3.Department of Diagnostic PathologyKasumigaura Medical CenterIbarakiJapan

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