Journal of Medical Ultrasonics

, Volume 45, Issue 1, pp 3–13 | Cite as

Attempt at standardization of bone quantitative ultrasound in Japan

  • Takahiko Otani
  • Masao Fukunaga
  • Kosei Yho
  • Takami Miki
  • Kaoru Yamazaki
  • Hideaki Kishimoto
  • Mami Matsukawa
  • Nobuyuki Endoh
  • Hiroyuki Hachiya
  • Hiroshi Kanai
  • Saeko Fujiwara
  • Yoshinori Nagai
Review Article


Dual X-ray absorptiometry (DXA) is used to diagnose osteoporosis. On the other hand, quantitative ultrasound (QUS) is widely used to assess bone density as part of medical screening as it is relatively inexpensive and easy to perform. Current QUS devices do not share precise ultrasound-related parameters, such as frequency, waveform, beam pattern, transient response, definition of propagation time, definition of degree of attenuation, and precise measurement site, resulting in different measurements across models. The Japan Osteoporosis Society established a QUS Standardization Committee in 2007 to investigate standardization of speed of sound (SOS) and broadband ultrasonic attenuation (BUA) measurements to resolve this issue. The committee came up with a formula to convert SOS and BUA values yielded by each model available in Japan. This has made it possible to convert QUS measurements from different models into standardized values, greatly improving the effectiveness of QUS measurements.


Quantitative ultrasound (QUS) Speed of sound (SOS) Broadband ultrasonic attenuation (BUA) Standardization of QUS 



We wish to express our gratitude to Mr. Kaoru Horii (OYO Electric Co., Ltd.), who helped process an enormous amount of data in this study of QUS standardization.

Compliance with ethical standards

Ethical statements

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

Conflict of interest

The authors declare that there is no conflict of interest.

Informed consent

Informed consent was obtained from all subjects (volunteers) for being included in the study.


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Copyright information

© The Japan Society of Ultrasonics in Medicine 2017

Authors and Affiliations

  • Takahiko Otani
    • 1
  • Masao Fukunaga
    • 2
  • Kosei Yho
    • 3
  • Takami Miki
    • 4
  • Kaoru Yamazaki
    • 5
  • Hideaki Kishimoto
    • 6
  • Mami Matsukawa
    • 1
  • Nobuyuki Endoh
    • 7
  • Hiroyuki Hachiya
    • 8
  • Hiroshi Kanai
    • 9
  • Saeko Fujiwara
    • 10
  • Yoshinori Nagai
    • 11
  1. 1.Faculty of Science and EngineeringDoshisha UniversityKyotanabeJapan
  2. 2.Kawasaki Medical SchoolOkayamaJapan
  3. 3.Aino HospitalOsakaJapan
  4. 4.Izumiotsu Municipal HospitalOsakaJapan
  5. 5.Department of Orthopedic SurgeryIwata City HospitalShizuokaJapan
  6. 6.Department of Orthopedic SurgeryNojima HospitalTottoriJapan
  7. 7.Department of Electric, Electronics, and Information Engineering, Faculty of EngineeringKanagawa UniversityKanagawaJapan
  8. 8.School of EngineeringTokyo Institute of TechnologyTokyoJapan
  9. 9.Graduate Schools of Engineering and Biomedical EngineeringTohoku UniversityMiyagiJapan
  10. 10.Health Management and Promotion CenterHiroshima Atomic Bomb Casualty CouncilHiroshimaJapan
  11. 11.TM Clinical Support Co. Ltd.TokyoJapan

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