Measurement of carotid pulse wave velocity using ultrafast ultrasound imaging in hypertensive patients
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The study aimed to assess the utility of ultrafast ultrasound imaging for evaluation of carotid pulse wave velocity (PWV) in newly diagnosed hypertension patients.
This prospective non-randomized study enrolled 90 hypertensive patients in our hospital from September to December 2013 as a hypertension group. An age- and sex-matched cohort of 50 healthy adults in our hospital from September to December 2013 was also included in the study as a control group. Carotid PWV at the beginning and at the end of systole (PWV-BS and PWV-ES, respectively) and intima-media thickness (IMT) were measured by ultrafast ultrasound imaging technology. The associations of PWV-BS, PWV-ES, and IMT with hypertension stage were evaluated by Spearman correlation analysis.
PWV-BS and PWV-ES in the hypertension group were significantly elevated compared with those in control group. Different hypertension stages significantly differed in PWV-BS and PWV-ES. PWV-BS and PWV-ES appeared to increase with the hypertension stage. Moreover, IMT, PWV-BS, and PWV-ES were positively correlated with the hypertension stage in hypertensive patients.
Ultrafast ultrasound imaging was a valid and convenient method for the measurement of carotid PWV in hypertensive patients. Ultrafast ultrasound imaging might be recommended as a promising alternative method for early detection of arterial abnormality in clinical practice.
KeywordsUltrafast ultrasound imaging Essential hypertension Carotid artery elasticity Carotid pulse wave velocity
Compliance with ethical standards
Conflict of interest
The study was approved by the medical ethics committee of the Second Affiliated Hospital of Xi’an Jiaotong University, and written informed consent was received from each participant.
- 1.Organization WH. A global brief on hypertension: silent killer, global public health crisis. Geneva: WHO; 2013. http://www.who.int/iris/handle/10665/79059
- 2.Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Press. 2013;22:193–278.CrossRefGoogle Scholar
- 7.Mitchell GF. Arterial stiffness and hypertension. Hypertension. 2014;64:37–46.Google Scholar
- 12.Kim ST, Najjar SS, Boudreau RM, et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation. 2006;111:3384–90.Google Scholar
- 18.Couade M, Flanagan C, Lee WN, et al. Evaluation of local arterial stiffness using ultrafast imaging: a comparative study using local arterial pulse wave velocity estimation and shear wave imaging. Ultrasonics Symposium (IUS), 2010 IEEE; 2010: IEEE.Google Scholar
- 31.Koivistoinen T, Virtanen M, Hutri-Kähönen N, et al. Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis. 2012;220:387–93.CrossRefPubMedGoogle Scholar