Journal of Medical Ultrasonics

, Volume 33, Issue 2, pp 77–83 | Cite as

A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography

  • Satoshi Yamada
  • Kaoru Komuro
  • Mariko Taniguchi
  • Ayumi Uranishi
  • Hiroshi Komatsu
  • Toshihiko Asanuma
  • Fuminobu Ishikura
  • Hisao Onozuka
  • Taisei Mikami
  • Hiroyuki Tsutsui
  • Shintaro Beppu
ORIGINAL ARTICLE

Abstract

Purpose

In high mechanical index (MI) contrast ultrasonography it has been shown that the power of contrast signal intensity (CI) has a strong linear correlation with the concentration of the ultrasound contrast agent under conditions of constant applied acoustic pressure. However, it is unclear whether the linearity is preserved in low-MI contrast ultrasonography. Thus, we investigated the relationship between ultrasound contrast concentration and CI in vitro.

Methods

Solutions of the ultrasound contrast agents Definity and Imagent were prepared at concentrations of 0.5, 2, 8, 32, and 128 μl/l. Placing a jelly block between the transducer and the solution, the solutions were transmitted using pulse subtraction imaging with an MI of 0.05, 0.1, and 0.5. CI was measured in dB in a region of interest 3 mm in height placed just below the border between the jelly and the solution. Data were plotted using double logarithm scales, where the concentration was expressed in dB as 10 × log (concentration).

Results

CI in dB had a strong linear correlation with concentration in dB for both agents with any MI. Best fitted slopes were close to 1, indicating that the power of CI is proportional to the concentration.

Conclusions

In low-MI contrast ultrasonography, the power of CI is proportional to contrast concentration, and CI in dB is logarithmic to the concentration. Thus, the microbubble concentration can be quantitatively measured even in low-MI contrast ultrasonography.

Key words

contrast agent contrast ultrasonography pulse subtraction imaging mechanical index 

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Copyright information

© The Japan Society of Ultrasonics in Medicine 2006

Authors and Affiliations

  • Satoshi Yamada
    • 1
  • Kaoru Komuro
    • 2
  • Mariko Taniguchi
    • 3
  • Ayumi Uranishi
    • 3
  • Hiroshi Komatsu
    • 1
  • Toshihiko Asanuma
    • 3
  • Fuminobu Ishikura
    • 3
  • Hisao Onozuka
    • 1
  • Taisei Mikami
    • 4
  • Hiroyuki Tsutsui
    • 1
  • Shintaro Beppu
    • 3
  1. 1.Department of Cardiovascular MedicineHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Department of Clinical ResearchHakodate National HospitalHakodateJapan
  3. 3.School of Allied Health SciencesOsaka University Faculty of MedicineOsakaJapan
  4. 4.Department of Health SciencesHokkaido University School of MedicineSapporoJapan

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