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EcoHealth

, Volume 5, Issue 4, pp 456–459 | Cite as

Mercury Toxicity and the Mitigating Role of Selenium

  • Marla J. BerryEmail author
  • Nicholas V. C. Ralston
Forum

Abstract

Mercury is a well-known environmental toxicant, particularly in its most common organic form, methylmercury. Consumption of fish and shellfish that contain methylmercury is a dominant source of mercury exposure in humans and piscivorous wildlife. Considerable efforts have focused on assessment of mercury and its attendant risks in the environment and food sources, including the studies reported in this issue. However, studies of mercury intoxication have frequently failed to consider the protective effects of the essential trace element, selenium. Mercury binds to selenium with extraordinarily high affinity, and high maternal exposures inhibit selenium-dependent enzyme activities in fetal brains. However, increased maternal dietary selenium intakes preserve these enzyme activities, thereby preventing the pathological effects that would otherwise arise in their absence. Recent evidence indicates that assessments of mercury exposure and tissue levels need to consider selenium intakes and tissue distributions in order to provide meaningful risk evaluations.

Keywords

mercury selenium toxicity environment heavy metals 

Notes

Acknowledgments

MJB is supported by the NIH. NVCR is supported by the EPA and NOAA.

References

  1. Bulato C, Bosello V, Ursini F, Maiorino M (2007) Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cells. Free Radical Biology and Medicine 42:118–123CrossRefGoogle Scholar
  2. Chapman L, Chan HM (2000) The influence of nutrition on methylmercury intoxication. Environmental Health Perspectives 108:29–56CrossRefGoogle Scholar
  3. Chen C, Yu H, Zhao J, Li B, Qu L, Liu S, et al. (2006) The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure. Environmental Health Perspectives 114:297–301Google Scholar
  4. Chen CY, Serrell N, Evers DC, Fleishman BJ, Lambert KF, Weiss J, et al. (2008) Methylmercury in marine ecosystems: from sources to seafood consumers—a workshop report. Environmental Health Perspectives; DOI: 10.1289/ehp.1121
  5. Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review. Ecotoxicology and Environmental Safety 21:348–364CrossRefGoogle Scholar
  6. Driscoll C, Han YJ, Chen CY, Evers DC, Lambert KF, Holsen TM, et al. (2007) Mercury contamination in forest and freshwater ecosystems in the northeastern United States. Bioscience 57:17–28CrossRefGoogle Scholar
  7. Dyrssen D, Wedborg M (1991) The sulfur–mercury(II) system in natural waters. Water, Air, and Soil Pollution 56:507–519CrossRefGoogle Scholar
  8. Falnoga I, Tusek-Znidaric M, Stegnar P (2006) The influence of long-term mercury exposure on selenium availability in tissues: an evaluation of data. BioMetals 19:283–294CrossRefGoogle Scholar
  9. Koelman JH, Peeters WHM, Koudstaal-Hol CHM (1973) Mercury-selenium correlations in marine mammals. Nature 245:385–386CrossRefGoogle Scholar
  10. Kosta L, Byrne AR, Zelenko V (1975) Correlation between selenium and mercury in man following exposure to inorganic mercury. Nature 254:238–239CrossRefGoogle Scholar
  11. Mergler D, Anderson HA, Chan HM, Mahaffey KR, Murray M, Sakamoto M, et al. (2007) Methylmercury exposure and health effects in humans: a worldwide concern. Ambio 36:3–11CrossRefGoogle Scholar
  12. Mostert V, Lombeck I, Abel J (1998). A novel method for the purification of Selenoprotein P from human plasma. Archives of Biochemisty and Biophysics 357:326-330Google Scholar
  13. Ralston NVC, Blackwell JL, Raymond LJ (2007) Importance of molar ratios in selenium-dependent protection against methylmercury toxicity. Biological Trace Element Research 119:255–268CrossRefGoogle Scholar
  14. Ralston NVC, Ralston CR, Blackwell JL III, Raymond LJ (2008) Dietary and tissue selenium in relation to methylmercury toxicity. Neurotoxicology 29:802–811CrossRefGoogle Scholar
  15. Raymond LJ, Ralston NVC (2004) Mercury: selenium interactions and health implications. Seychelles Medical and Dental Journal 7:72–77Google Scholar
  16. Sasakura C, Suzuki KT (1998) Biological interaction between transition metals (Ag, Cd and Hg), selenide/sulfide and selenoprotein P. Journal of Inorganic Biochemistry 71:159–162CrossRefGoogle Scholar
  17. Scheuhammer AM, Meyer MW, Sandheinrich MB, Murray MW (2007) Effects of environmental methylmercury on the health of wild birds, mammals, and fish. Ambio 36:12–18CrossRefGoogle Scholar
  18. Sunderland EM (2007) Mercury exposure from domestic and imported estuarine and marine fish in the U.S. seafood market. Environmental Health Perspectives 115:235–242CrossRefGoogle Scholar
  19. Takeuchi T, Morikawa N, Matsumoto H, Shiraishi Y (1962) A pathological study of Minamata disease in Japan. Acta Neuropathologica 2:40–57CrossRefGoogle Scholar
  20. Watanabe C, Yoshida K, Kasanuma Y, Kun Y, Satoh H (1999) In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Environmental Research 80:208–214CrossRefGoogle Scholar
  21. Yan J, Barrett JN (1998). Purification from Bovine serum of a survival-promoting factor for cultured central neurons and its identification as Selenoprotein-P. Journal of Neuroscience 18:8682-8691Google Scholar
  22. Yoneda S, Suzuki KT (1997) Equimolar Hg-Se complex binds to selenoprotein P. Biochemical and Biophysical Research Communications 231: 7–11CrossRefGoogle Scholar

Copyright information

© International Association for Ecology and Health 2009

Authors and Affiliations

  1. 1.Department of Cell and Molecular Biology, John A. Burns School of MedicineUniversity of Hawaii at ManoaHonoluluUSA
  2. 2.Energy and Environmental Research CenterUniversity of North DakotaGrand ForksUSA

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