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Journal of Public Health

, Volume 27, Issue 6, pp 803–813 | Cite as

Risk of major cancers associated with various forms of tobacco use in India: a systematic review and meta-analysis

  • Jang Bahadur PrasadEmail author
  • Murali Dhar
Original Article

Abstract

Background

Several studies have established the association of various cancers with tobacco consumption. However, hardly any attempt has been made to examine the combined effect of various forms of tobacco consumption. Hence, the present study was undertaken to measure the overall risk of different cancer sites associated with various forms of tobacco used individually or in combination, and to investigate the risk variation within each site by different forms of use.

Methods

Meta-analysis was carried out on the findings of 22 published studies of samples exposed to tobacco use and control groups that were not exposed to tobacco. The pooled odds ratios (ORs) for each cancer for different combinations of forms of tobacco were calculated using a random effects model.

Results

Smoking was found to be associated with a 5-fold higher risk of oropharynx, larynx, and lung, a 3-fold higher risk of hypopharynx, and esophagus, and a 2-fold higher risk of oral cancer. Esophagus (OR = 3.5) and oral cancer were the only sites significantly associated with tobacco chewing. The OR associated with bidi smoking was highest for lung (6-fold) followed by esophagus (3.5-fold) and oral cancer (3-fold). Lung cancer was also significantly associated with cigarette smoking.

Conclusions

The present study reported pooled ORs for different tobacco-related cancers associated with various forms of tobacco use, both individually as well as in various combinations. Collecting data on the consumption of tobacco is a complex exercise. Pooled ORs reported in this study will be useful in working out the quantum of diverse tobacco-related cancers attributable to different forms of tobacco consumption, both individually as well as in combination.

Keywords

Bidi Cigarette Smoking Chewing Cancer Meta-analysis India 

Notes

Compliance with ethical standards

Ethical approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of supporting data

This meta-analysis study was based on secondary data sources (published studies).

Competing interests

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.International Institute for Population SciencesMumbaiIndia
  2. 2.Department of Population Policies & ProgrammesInternational Institute for Population SciencesMumbai, 400088India

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