Journal of Public Health

, Volume 18, Issue 3, pp 237–244 | Cite as

Environmental risk factors affecting transmission of Helicobacter pylori infection in Egypt

  • Hala Ibrahim Awdalla
  • Moustfa Hassan Ragab
  • Lilian Nabil Hanna
Original Article

Abstract

Background

Helicobacter pylori (H. pylori) infection varies remarkably between and within populations suggesting the role of socioeconomic-related environmental factors.

Aim

The aim of this study was to determine the prevalence of H. pylori among the studied population, to explore the effect of some environmental risk factors and lifestyle on the transmission of infection, and to study the association between this H. pylori bacterium and various noncontagious diseases.

Method

This cross-sectional study was conducted over 6 months in two Egyptian health clinics. Two hundred apparently healthy individuals from rural (Unshass) and urban (Nasr City) areas voluntarily participated in this study. A full detailed clinical assessment in the form of a questionnaire was designed for each individual to determine risk factors with specific emphasis on age, sex, and residence. The seroprevalence of H. pylori IgG antibodies was evaluated using the enzyme-linked immunosorbent assay (ELISA).

Results

In the urban group 28 subjects (28%) were H. pylori positive versus 54 subjects (54%) in the rural group. A significant relationship between H. pylori and poor sanitary conditions was detected; there was an association between H. pylori prevalence and gastric diseases, hepatic diseases, and hyperglycemia suggesting diabetes.

Conclusion

H. pylori infection was nearly twice as high in the rural group than in the urban one.

Keywords

H. pylori Rural Urban Sociodemographic 

References

  1. Alempijević T, Krstić M, Antonić V, Krstić S (2007) Frequency of Helicobacter pylori infection in patients with liver cirrhosis (in Serbian). Srp Arh Celok Lek 135(9–10):536–540PubMedGoogle Scholar
  2. Almadi MA, Aljebreen AM, Tounesi FA, Abdo AA (2007) Helicobacter pylori prevalence among medical students in a high endemic area. Saudi Med J 28:896–898PubMedGoogle Scholar
  3. Amital H, Govoni M, Maya R, Meroni PL, Ori B, Shoenfeld Y, Tincani A, Trotta F, Sarzi-Puttini P, Atzeni F (2008) Role of infectious agents in systemic rheumatic diseases. Clin Exp Rheumatol 26(1 Suppl 48):S27–S32PubMedGoogle Scholar
  4. Bener A, Micallef R, Afifi M, Derbala M, Al-Mulla HM, Usmani MA (2007) Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk J Gastroenterol 18(4):225–229PubMedGoogle Scholar
  5. Bhuiyan TR, Qadri F, Saha A, Svennerholm AM (2009) Infection by Helicobacter pylori in Bangladeshi children from birth to two years: relation to blood group, nutritional status, and seasonality. Pediatr Infect Dis J 28(2):79–85CrossRefPubMedGoogle Scholar
  6. Bruce MG, Maaroos HI (2008) Epidemiology of Helicobacter pylori infection. Helicobacter 13(Suppl 1):1–6 ReviewCrossRefPubMedGoogle Scholar
  7. Cheng H, Hu F, Zhang L, Yang G, Ma J, Hu J, Wang W, Gao W, Dong X (2009) Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China. Helicobacter 14(2):128–133CrossRefPubMedGoogle Scholar
  8. Czinn SJ (2005) Helicobacter pylori infection: detection, investigation, and management. J Pediatr 146(3 Suppl):S21–S26PubMedGoogle Scholar
  9. Do MY, Lee YC, Choi CH, Kim SJ, Mun CS, Moon HJ, Lee HW, Oh HC, Kim HJ, Kim JW, Do JH, Kim JG, Chang SK (2009) The changes in prevalence and the related factors of Helicobacter pylori infection in Korean health check-up subjects during 8 years (in Korean). Korean J Gastroenterol 53(2):76–83PubMedGoogle Scholar
  10. Ghil HM, Yoo JH, Jung WS, Chung TH, Youn HY, Hwang CY (2009) Survey of Helicobacter infection in domestic and feral cats in Korea. J Vet Sci 10(1):67–72CrossRefPubMedGoogle Scholar
  11. Gisbert JP, Moreno-Otero R, Pajares JM (2002) Prevalence of Helicobacter pylori infection in chronic liver disease and relationship with its complications: systematic review and meta-analysis (in Spanish). Med Clin (Barc) 119(12):464–474Google Scholar
  12. Grübel P, Hoffman JS, Chong FK, Burstein NA, Mepani C, Cave DR (1997) Vector potential of houseflies (Musca domestica) for Helicobacter pylori. J Clin Microbiol 35(6):1300–1303PubMedGoogle Scholar
  13. Gulcelik NE, Kaya E, Demirbas B, Culha C, Koc G, Ozkaya M, Cakal E, Serter R, Aral Y (2005) Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 28(3):214–217PubMedGoogle Scholar
  14. Ito LS, Oba-Shinjo SM, Marie SK, Uno M, Shinjo SK, Hamajima N, Tajima K, Tominaga S (2003) Lifestyle factors associated with atrophic gastritis among Helicobacter pylori-seropositive Japanese-Brazilians in São Paulo. Int J Clin Oncol 8(6):362–368CrossRefPubMedGoogle Scholar
  15. Ito K, Yamaoka Y, Ota H, El-Zimaity H, Graham DY (2008) Adherence, internalization, and persistence of Helicobacter pylori in hepatocytes. Dig Dis Sci 53(9):2541–2549CrossRefPubMedGoogle Scholar
  16. Kanbay M, Gür G, Arslan H, Yilmaz U, Boyacioglu S (2005) The relationship of ABO blood group, age, gender, smoking and Helicobacter pylori infection. Dig Dis Sci 50(7):1214–1217CrossRefPubMedGoogle Scholar
  17. Kandulski A, Selgrad M, Malfertheiner P (2008) Helicobacter pylori infection: a clinical overview. Dig Liver Dis 40(8):619–626CrossRefPubMedGoogle Scholar
  18. Kusters JG, van Vliet AH, Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19(3):449–490CrossRefPubMedGoogle Scholar
  19. Lutsey PL, Pankow JS, Bertoni AG, Szklo M, Folsom AR (2009) Serological evidence of infections and type 2 diabetes: the MultiEthnic Study of Atherosclerosis. Diabet Med 26(2):149–152CrossRefPubMedGoogle Scholar
  20. Marakoğlu K, Eke AA, Civi S (2008) Smoking as an important factor increasing risk of Helicobacter pylori. Turk J Gastroenterol 19(2):133–134PubMedGoogle Scholar
  21. Moayyedi P, Axon AT, Feltbower R et al (2002) Relation of adult lifestyle and socioeconomic factors to the prevalence of Helicobacter pylori infection. Int J Epidemiol 31(3):624–631CrossRefPubMedGoogle Scholar
  22. Osato MS, Ayub K, Le HH, Reddy R, Graham DY (1998) Houseflies are an unlikely reservoir or vector for Helicobacter pylori. J Clin Microbiol 36(9):2786–2788PubMedGoogle Scholar
  23. Raymond J, Thiberge JM, Kalach N, Bergeret M, Dupont C, Labigne A, Dauga C (2008) Using macro-arrays to study routes of infection of Helicobacter pylori in three families. PLoS One 3(5):e2259CrossRefPubMedGoogle Scholar
  24. Salem OE, Youssri AH, Mohammad ON (1993) The prevalence of H. pylori antibodies in asymptomatic young egyptian persons. J Egypt Public Health Assoc 68(3–4):333–352PubMedGoogle Scholar
  25. Santacroce L, Miragliotta G, Bhutani MS (2005) Helicobacter pylori infection. http://www.emedicine.com/MED/topic962.htm. Accessed 21 Jan 2009
  26. Santos IS, Boccio J, Davidsson L, Hernandez-Triana M, Huanca-Sardinas E, Janjetic M, Moya-Camarena SY, Paez-Valery MC, Ruiz-Alvarez V, Valencia ME, Valle NC, Vargas-Pinto G, Solano L, Thomas J (2009) Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela. Public Health Nutr 12:1862–1870CrossRefPubMedGoogle Scholar
  27. Sari YS, Can D, Tunali V, Sahin O, Koc O, Bender O (2008) H pylori: treatment for the patient only or the whole family? World J Gastroenterol 14(8):1244–1247CrossRefPubMedGoogle Scholar
  28. Sasidharan S, Uyub AM (2009) Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in Northern Peninsular Malaysia. Trans R Soc Trop Med Hyg 103(4):395–398CrossRefPubMedGoogle Scholar
  29. Sayed ASM, Abd Al-Azeem MW, Noaman HA, Hassan MA (2007) Seroepidemiological study on Helicobacter pylori infection in children and adults in Assiut Governorate, Upper Egypt. JASMR 2(2):129–133Google Scholar
  30. Sedlácková M, Malaty H, Volf V, Frühauf P, Marx D, Soucek A, Graham DY (2003) Helicobacter pylori infection in a group of symptomatic and asymptomatic children and adolescents in the Czech Republic (in Czech). Cas Lek Cesk 142(2):102–105PubMedGoogle Scholar
  31. Seyda T, Derya C, Füsun A, Meliha K (2007) The relationship of Helicobacter pylori positivity with age, sex, and ABO/Rhesus blood groups in patients with gastrointestinal complaints in Turkey. Helicobacter 12(3):244–250CrossRefPubMedGoogle Scholar
  32. Siai K, Ghozzi M, Ezzine H, Medjahed N, Azzouz MM (2008) Prevalence and risk factors of Helicobacter pylori infection in Tunisian children: 1055 children in Cap-Bon (northeastern Tunisia). Gastroenterol Clin Biol 32(11):881–886CrossRefPubMedGoogle Scholar
  33. Stettin D, Waldmann A, Wolters M, Trunz B, Schauder P, Hahn A (2007) Infection with Helicobacter pylori—outcome of a cross-sectional investigation (in German). Dtsch Med Wochenschr 132(50):2677–2682CrossRefPubMedGoogle Scholar
  34. Sugiyama T, Yoshioka M, Furuta Y, Miyasaka K (2004) What is Helicobacter pylori?: associated diseases in human (in Japanese). Hokkaido Igaku Zasshi 79(2):111–115PubMedGoogle Scholar
  35. Vcev A, Nakić D, Mrden A, Mirat J, Balen S, Ruzić A, Persić V, Soldo I, Matijević M, Barbić J, Matijević V, Bozić D, Radanović B (2007) Helicobacter pylori infection and coronary artery disease. Coll Antropol 31(3):757–760PubMedGoogle Scholar
  36. Yucel T, Aygin D, Sen S, Yucel O (2008) The prevalence of Helicobacter pylori and related factors among university students in Turkey. Jpn J Infect Dis 61(3):179–183PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hala Ibrahim Awdalla
    • 1
    • 3
  • Moustfa Hassan Ragab
    • 1
  • Lilian Nabil Hanna
    • 2
  1. 1.Institute of Environmental Studies and ResearchAin Shams UniversityCairoEgypt
  2. 2.Nuclear Materials AuthorityCairoEgypt
  3. 3.Medical Science Department, Institute of Environmental Studies and ResearchAin Shams UniversityAbbassia, CairoEgypt

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