, Volume 16, Issue 1, pp 63–70 | Cite as

Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

  • Tetsuya AbeEmail author
  • Takahiro Hosoi
  • Ryosuke Kawai
  • Norihisa Uemura
  • Eiji Higaki
  • Byonggu An
  • Jiro Kawakami
  • Takuya Saito
  • Yasuhiro Shimizu
Original Article



We clarified the effects of perioperative enteral supplementation with glutamine, fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.


Of 326 patients with esophageal cancer, 189 received GFO administration (GFO group) and 137 did not (control group). The propensity score matching method was used to identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters and clinical and postoperative outcomes.


The duration of the systemic inflammatory response syndrome (SIRS) was significantly shorter in the GFO group compared to the control group (p = 0.002). Moreover, the lymphocyte/neutrophil ratio (L/N ratio) had significantly recovered in the GFO group on postoperative day-3, and the CRP value was significantly lower in the GFO group than that in the control group on postoperative day-2.


Perioperative use of enteral supplementation with glutamine, fiber, and oligosaccharide likely contributes to a reduction in early surgical stress after an esophagectomy. These beneficial effects can bring about early recovery from postoperative immunosuppressive conditions after radical esophagectomy.


Esophagectomy Surgical stress Nutrition 



The authors thank Professor Kenichi Yoshimura (Innovative Clinical Research Center, Kanazawa University) for guidance on statistical analysis.

Compliance with ethical standards

Ethical statement

This was a retrospective study approved by the review board of the Aichi Cancer Center Hospital.

Conflict of interest

The authors have no conflicts of interest to disclose.


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Copyright information

© The Japan Esophageal Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Gastroenterological SurgeryAichi Cancer Center HospitalNagoyaJapan

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