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Esophagus

, Volume 10, Issue 3, pp 174–178 | Cite as

Therapy-related acute myeloid leukemia following postoperative adjuvant chemotherapy including cisplatin and fluorouracil for esophageal carcinoma

  • Masahiro ManabeEmail author
  • Kinshi Kosaka
  • Hirofumi Nakano
  • Teruhito Takakuwa
  • Naonori Harada
  • Shuichiro Okamoto
  • Yasutaka Aoyama
  • Takeo Kumura
  • Tadanobu Ohta
  • Yoshio Furukawa
  • Kazuhiro Takeuchi
  • Atsuko Mugitani
Case Report
  • 115 Downloads

Abstract

We report a case of therapy-related acute myeloid leukemia (t-AML), which developed following chemotherapy involving cisplatin and 5-fluorouracil for esophageal carcinoma. A 70-year-old man with past history of esophageal carcinoma, which was treated with subtotal esophagectomy 32 months earlier followed by 2 courses of chemotherapy involving cisplatin and 5-fluorouracil, was diagnosed with t-AML. His leukemia was resistant to chemotherapy, and the patient died from pneumonia 4 months after being diagnosed with leukemia. Although treatment for esophageal carcinoma is associated with a markedly lower frequency of therapy-related myeloid neoplasms than treatment for certain other malignancies such as hematological neoplasms, it is important to be aware that therapy-related myeloid neoplasms can occur as late complications of esophageal carcinoma treatment.

Keywords

Therapy-related myeloid neoplasms Esophageal carcinoma Fluorouracil Cisplatin 

Notes

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Japan Esophageal Society and Springer Japan 2013

Authors and Affiliations

  • Masahiro Manabe
    • 1
    Email author
  • Kinshi Kosaka
    • 2
  • Hirofumi Nakano
    • 1
  • Teruhito Takakuwa
    • 1
  • Naonori Harada
    • 1
  • Shuichiro Okamoto
    • 1
  • Yasutaka Aoyama
    • 1
  • Takeo Kumura
    • 1
  • Tadanobu Ohta
    • 1
  • Yoshio Furukawa
    • 1
  • Kazuhiro Takeuchi
    • 2
  • Atsuko Mugitani
    • 1
  1. 1.Department of HematologySeichokai Fuchu HospitalIzumiJapan
  2. 2.Department of SurgerySeichokai Fuchu HospitalIzumiJapan

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