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Comparative study of topical regimen for adenoviral kearoconjunctivitis by 0.1% fluorometholone with and without polyvinyl alcohol iodine

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Abstract

Purpose

The aim of this study was to compare the efficacy of the topical regimens of iodine/steroids vs. antibiotics/steroids in acute to subacute adenoviral keratoconjunctivitis.

Study design

A prospective open-label study.

Patients and methods

Nineteen patients diagnosed with unilateral or bilateral adenoviral conjunctivitis at less than 1 week from onset were enrolled in this study. Patients were divided randomly into two groups; group 1 was treated with 1.5% levofloxacin with 0.1% fluorometholone administered four times a day and group 2 was treated with a sixfold dilution of polyvinyl alcohol iodine (PAI) solution with 0.1% fluorometholone four times a day. Conjunctival samples from all affected eyes were obtained for real-time PCR. The total scores of acute signs (i.e., eyelid edema, conjunctival injecton, conjunctival discharge, follicules, pseudomembranes, subconjunctival hemorrhage) and symptoms, HAdV DNA copy number, and the presence of multiple subepithelial corneal infiltrates (MSI) were evaluated every 5 visits up to Day 30 after diagnosis.

Results

Comparing the total scores of acute signs and symptoms and viral load, we observed no significant differences between the two groups. At day 15 after diagnosis the proportion of patients with MSI in group 2 (35.7%) was significantly lower than in group 1 (0%).

Conclusions

The impact of topical iodine/steroid therapy on acute signs and symptoms associated with adenoviral conjunctivitis is limited and not substantially different in the responses to antibiotics/steroids. However, this regimen results in a significant decrease in the incidence of MSI during the subacute phase of infection.

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Authors and Affiliations

  1. Department of Ophthalmology, Nojima Hospital, 2714-1, Sesaki-machi, Kurayoshi-city, Tottori, 682-0863, Japan

    Kazuki Matsuura & Yuki Terasaka

  2. Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1, Nishi-cho, Yonago-city, Tottori, 683-8504, Japan

    Dai Miyazaki, Yumiko Shimizu & Yoshitsugu Inoue

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  1. Kazuki Matsuura
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  2. Yuki Terasaka
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  3. Dai Miyazaki
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  4. Yumiko Shimizu
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  5. Yoshitsugu Inoue
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Corresponding author

Correspondence to Kazuki Matsuura.

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Conflicts of interest

K. Matsuura, None; Y. Terasaka, None; D. Miyazaki, Lecture fee (Santen, Senju, Alcon); Y. Shimizu, None; Y. Inoue, None.

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Corresponding Author: Kazuki Matsuura

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Matsuura, K., Terasaka, Y., Miyazaki, D. et al. Comparative study of topical regimen for adenoviral kearoconjunctivitis by 0.1% fluorometholone with and without polyvinyl alcohol iodine. Jpn J Ophthalmol 65, 107–114 (2021). https://doi.org/10.1007/s10384-020-00788-3

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  • DOI: https://doi.org/10.1007/s10384-020-00788-3

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