Japanese Journal of Ophthalmology

, Volume 63, Issue 1, pp 65–72 | Cite as

Current status of late and recurrent intraocular lens dislocation: analysis of real-world data in Japan

  • Sumihiro Kawano
  • Masato Takeuchi
  • Shiro Tanaka
  • Takehiro Yamashita
  • Taiji Sakamoto
  • Koji KawakamiEmail author
Clinical Investigation



To describe relevant patient demographic characteristics and investigate the influence of known risk factors for late intraocular lens (IOL) dislocation. To explore the associations between these risk factors and the incidence of recurrent IOL dislocation.

Study design

Retrospective cohort study.


This study was performed using Nationwide Diagnostic Procedure Combination data in Japan from April 1, 2008 through July 31, 2016. Descriptive statistics for late and recurrent IOL dislocation, incidence rates, and risk factors for recurrent IOL dislocation were analyzed using a Cox proportional hazard model.


We identified 678 patients with late IOL dislocation. Most were men (72%, 488/678), and the men were younger than their women counterparts (mean age 65.2 years vs. 74.5 years). The incidence rate of recurrent IOL dislocation was 5.1 per 100 person-years. All 20 cases of recurrent IOL dislocation were observed within the year following surgery. There were no significant associations between potential risk factors and recurrent IOL dislocation (adjusted hazard ratio [HR] 1.53, 95% confidence interval [CI] 0.55–4.26 for diabetes mellitus; adjusted HR 0.77, 95%CI 0.09–6.40 for atopic dermatitis); no recurrences occurred in patients with pseudoexfoliation syndrome, retinitis pigmentosa, or connective tissue disease.


Late IOL dislocation occurs more frequently in men. We found that recurrent IOL dislocation was rare during long-term follow-up and there were no significant associations between the potential risk factors and recurrent IOL dislocation. Further studies are needed to clarify the sex-related differences involved in IOL dislocation.


Late IOL dislocation Complications Risk factors Recurrent IOL dislocation Epidemiology 



The authors thank Dr. Toshifumi Yamashita for making useful comments on the study design.

Conflicts of interest

S. Kawano, None; M. Takeuchi, None; S. Tanaka, None; T. Yamashita, None; T. Sakamoto, None; K. Kawakami, Consultant fees (Kaken, Kyowa Hakko Kirin, Olympus, Otsuka), Honorarium (Behringer Ingelheim Japan, Daiichi Sankyo, Eisai, Mitsubishi Tanabe Pharma, Novartis, Sanofi, Shionogi, Takeda), Lecture fee (Santen).


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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Sumihiro Kawano
    • 1
    • 2
  • Masato Takeuchi
    • 2
  • Shiro Tanaka
    • 3
  • Takehiro Yamashita
    • 1
  • Taiji Sakamoto
    • 1
  • Koji Kawakami
    • 2
    Email author
  1. 1.Department of OphthalmologyKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  2. 2.Department of Pharmacoepidemiology, Graduate School of Medicine and Public HealthKyoto UniversityKyotoJapan
  3. 3.Department of Clinical Biostatistics, Graduate School of MedicineKyoto UniversityKyotoJapan

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