Japanese Journal of Ophthalmology

, Volume 63, Issue 2, pp 210–214 | Cite as

Periocular inverted follicular keratosis: a retrospective series over 17 years

  • Cecilia Díez-Montero
  • Diego González González
  • Elena Pérez Martínez
  • Silvana Schellini
  • Alicia Galindo-FerreiroEmail author
Clinical Investigation



To evaluate the demographic, clinical, and histopathologic characteristics of periocular inverted follicular keratosis (IFK), a very rare lesion with poorly defined characteristics.

Study design

Retrospective case series.


We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Data were collected on the patients’ demographics, clinical presentation and course of the disease, signs and symptoms, location of the lesion, and outcomes of treatment.


The patients’ mean age was 71 years (range, 32–91 years). Seven (64%) of the patients were female. Eight of the patients (72.7%) had no symptoms, two (18.2%) reported itching, and one (9.1%) had edema and bleeding of the lesion. The lesion affected the upper eyelid in 4 of the patients (36%), the lower lid in 3 of the patients (27%), and the inner canthus in 4 of the patients (36%).


IFK has no specific clinical characteristic and thus requires histologic confirmation for its diagnosis and appropriate management.


Inverted follicular keratosis Papilloma Periorbital 


Conflicts of interest

C. D.-Montero, None; D. G. González, None; E. P. Martinez, None; S. Schellini, None; A. G.-Ferreiro, None.


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Copyright information

© Japanese Ophthalmological Society 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyRio Hortega University HospitalValladolidSpain
  2. 2.Department of PathologyRio Hortega University HospitalValladolidSpain
  3. 3.Department of OphthalmologyKing Khaled Eye Specialist HospitalRiyadhSaudi Arabia

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