Japanese Journal of Ophthalmology

, Volume 60, Issue 2, pp 72–77 | Cite as

Association between glaucoma eye drops and hyperemia

  • Masahide YanagiEmail author
  • Yoshiaki Kiuchi
  • Yuki Yuasa
  • Tsuyoshi Yoneda
  • Tamaki Sumi
  • Yasuhiro Hoshikawa
  • Masahiko Kobayashi
  • Atsuki Fukushima
Clinical Investigation



We used an image analysis software program to quantitatively investigate conjunctival injection in patients treated with eye drops for glaucoma.


We compared 169 patients (89 men and 80 women) with a diagnosis of glaucoma. Photographs of the conjunctiva were taken on the temporal side of each patient’s right eye using a slit lamp. We determined the mean pixel frequencies of the conjunctival blood vessels from the photographs.


The ocular hyperemia of the patients being treated with prostaglandins was more severe than that of the patients being treated with beta-blockers or no eye drops. In multiple comparisons of each of the eye drops, the control group had a significantly lower degree of hyperemia than did the patients being treated with each of the various prostaglandin analogs (latanoprost, travoprost, tafluprost, and bimatoprost). Among the patients receiving prostaglandin, the percentage of those with hyperemia was highest in the bimatoprost users, followed in order by the travoprost, latanoprost, and tafluprost users. However, no significant differences were found among the different prostaglandin analogs in terms of the percentage of patients with hyperemia.


Our software program may be useful for evaluating the hyperemic effects of eye drops used for glaucoma. The particular type of prostaglandin analog seems to determine the level of conjunctival hyperemia during ocular hypotensive medical treatment.


Conjunctival injection Glaucoma Hyperemia Eye drops 


Conflicts of interest

M. Yanagi, Lecture fees (Santen); Y. Kiuchi, Commercial sponsor (Alcon, Pfizer, Santen, Senju); Y. Yuasa, None; T. Yoneda, Lecture fees (Kowa); T. Sumi, Lecture fees (Santen); Y. Hoshikawa, Employee (Nidek); M. Kobayashi, Employee (Nidek); A. Fukushima, Consultant fees (Alcon, Kissei, Kobayashi, Kowa, Kyowa-Kirin, Ohtsuka, Santen, Senju, Tanabe-Mitsubishi), P (License for Hyperemia-analyzing software).


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Copyright information

© Japanese Ophthalmological Society 2016

Authors and Affiliations

  • Masahide Yanagi
    • 1
    Email author
  • Yoshiaki Kiuchi
    • 1
  • Yuki Yuasa
    • 1
  • Tsuyoshi Yoneda
    • 2
  • Tamaki Sumi
    • 2
  • Yasuhiro Hoshikawa
    • 3
  • Masahiko Kobayashi
    • 3
  • Atsuki Fukushima
    • 2
  1. 1.Department of Ophthalmology and Visual SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of Ophthalmology and Visual ScienceKochi UniversityNankokuJapan
  3. 3.NIDEK CO. LTDGamagoriJapan

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