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Japanese Journal of Ophthalmology

, Volume 58, Issue 2, pp 177–187 | Cite as

Two types of acute zonal occult outer retinopathy differentiated by dark- and light-adapted perimetry

  • Kazuki KuniyoshiEmail author
  • Hiroyuki Sakuramoto
  • Yuzo Nakao
  • Chota Matsumoto
  • Yoshikazu Shimomura
Clinical Investigation

Abstract

Purpose

To assess the results of perimetry recorded under dark- and light-adapted (DA and LA) conditions in patients with acute zonal occult outer retinopathy (AZOOR) and to compare the results of electroretinography (ERG) and spectral-domain optical coherence tomography (SD-OCT) in two groups of AZOOR patients.

Methods

Twelve patients with AZOOR were studied. The diagnosis of AZOOR was based on the results of ophthalmoscopy, Goldmann kinetic perimetry, and multifocal ERGs. In addition, DA and LA perimetry, ERG, and SD-OCT were performed. The patients were followed for 1–9 years.

Results

The patients were classified into two types: type A patients (3) had a scotoma detected by both DA and LA perimetry, normal or equally abnormal cone and rod ERGs, atrophy of the outer nuclear layer (ONL), and disruption of the inner segment/outer segment (IS/OS) junction line in the OCT images. Type B patients (7) had a scotoma that was more prominent in LA than in DA perimetry and a continuous IS/OS junction line in the OCT images. Two patients had characteristics of both type A and type B AZOOR.

Conclusions

Our findings suggest that eyes with type A AZOOR have focal and severe impairment of both the rods and cones, and eyes with type B AZOOR have focal and specific impairment of the cones.

Keywords

Acute zonal occult outer retinopathy Perimetry Dark adaptation Light adaptation Electroretinography 

Notes

Acknowledgments

The authors express gratitude to Kazuyo Nakada-Omure, C.O., Department of Ophthalmology, Kinki University Faculty of Medicine, for her continuous technical assistance, especially for performing the dark- and light-adapted Goldmann kinetic perimetry for this research. This research was supported in part by research grants from the Japanese Ministry of Health, Labor, and Welfare, and from the Japan Society for the Promotion of Science.

Conflicts of interest

K. Kuniyoshi, None; H. Sakuramoto, None; Y. Nakao, None; C. Matsumoto, None; Y. Shimomura, None.

Supplementary material

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Copyright information

© Japanese Ophthalmological Society 2013

Authors and Affiliations

  • Kazuki Kuniyoshi
    • 1
    Email author
  • Hiroyuki Sakuramoto
    • 1
  • Yuzo Nakao
    • 1
  • Chota Matsumoto
    • 1
  • Yoshikazu Shimomura
    • 1
  1. 1.Department of OphthalmologyKinki University Faculty of MedicineOsaka-SayamaJapan

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