Intraobserver and interobserver agreement of computer software-assisted optic nerve head photoplanimetry
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To report the reproducibility profile of optic nerve head parameters obtained by computer software-assisted fundus photoplanimetry.
Fundus photographs obtained during a population-based health survey (Sakurae Study) were planimetrically analyzed using newly developed computer software, CDSketch. The parameters assessed included vertical and horizontal cup-to-disc (C/D) ratios, superior and inferior rim-to-disc (R/D) ratios, disc and cup vertical-to-horizontal (V/H) ratios, and disc-macular distance-to-disc diameter (DM/DD) ratio. For intraobserver and interobserver agreement assessments, we calculated the coefficients of variation (CVs) and intraclass correlation coefficients (ICCs) of the mean of three measurements obtained by one observer and a one-time measurement by three observers, respectively.
The intraobserver CVs were between 2.4 % (DM/DD ratio) and 11.0 % (inferior R/D ratio), and the ICCs were between 0.868 (cup V/H ratio) and 0.976 (DM/DD ratio); all intraobserver ICCs had almost perfect agreement (>0.81). The interobserver CVs were between 2.6 % (disc V/H ratio) and 18.0 % (inferior R/D ratio), and the ICCs were between 0.762 (cup V/H ratio) and 0.930 (DM/DD ratio); the interobserver ICCs were categorized as substantial (0.61–0.80) for the inferior R/D and cup V/H ratios and as almost perfect for the other five parameters.
The consistent profiles of the planimetric parameters suggest the suitability of software-assisted photoplanimetry for assessing optic disc characteristics in glaucoma clinical study and practice.
KeywordsCup-to-disc ratio Disc-macular distance-to-disc diameter (DM/DD) ratio Fundus-photo planimetry Intraclass correlation coefficient (ICC) Rim-to-disc ratio
This study was supported and conducted in part by the research project “The preventive study of critical diseases in the elderly through the application of the cohort framework” at the Center for Community-Based Health Research and Education (COHRE), Shimane University, Shimane Japan. The authors are grateful to Ms. Ryoko Takahashi for her technical assistance in digitization of the fundus films.
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