Japanese Journal of Ophthalmology

, Volume 57, Issue 4, pp 372–378 | Cite as

Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association

  • Yuko Iwasaki
  • Narumichi Yamamoto
  • Tatsushi Kawaguchi
  • Noriko Ozaki
  • Makoto Tomita
  • Atsushi Ajisawa
  • Manabu Mochizuki
  • Kimio Murakami
Clinical Investigation



To determine whether there is a significant association between human immunodeficiency virus (HIV)-related retinal microangiopathy and systemic cytomegalovirus (CMV) disease in HIV-infected patients.


Participants in this single-center, cross-sectional, retrospective study were 383 HIV-infected patients assessed for ocular manifestations before the beginning of antiretroviral therapy. The presence of HIV-related retinal microangiopathy, the presence of systemic CMV disease, laboratory data, and demographic information were determined by referring to medical records. The significance of any association between HIV-related retinal microangiopathy and systemic CMV disease was determined by use of the Chi-squared test and by multivariate analysis.


HIV-related retinal microangiopathy was present in 85 patients, and was significantly associated with systemic CMV disease both by use of the Chi-squared test (P = 0.006) and by multivariate analysis (P = 0.045, odds ratio 2.03, 95 % confidence interval 1.02–4.06 adjusted for CD4+ cell count and plasma HIV-RNA level).


These findings indicate that microangiopathy may be involved in the development of CMV disease in HIV-infected patients. Thus, detection of the presence of HIV-related retinal microangiopathy is important in the management of HIV-infected patients.


Microangiopathy Cotton-wool spots Cytomegalovirus Human immunodeficiency virus Acquired immune deficiency syndrome 


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Copyright information

© Japanese Ophthalmological Society 2013

Authors and Affiliations

  • Yuko Iwasaki
    • 1
    • 3
  • Narumichi Yamamoto
    • 1
  • Tatsushi Kawaguchi
    • 1
    • 3
  • Noriko Ozaki
    • 1
  • Makoto Tomita
    • 4
  • Atsushi Ajisawa
    • 2
  • Manabu Mochizuki
    • 3
  • Kimio Murakami
    • 1
  1. 1.Department of OphthalmologyTokyo Metropolitan Komagome HospitalBunkyoJapan
  2. 2.Department of Infectious DiseasesTokyo Metropolitan Komagome HospitalBunkyoJapan
  3. 3.Department of Ophthalmology and Visual ScienceTokyo Medical and Dental UniversityBunkyoJapan
  4. 4.Clinical Research CenterTokyo Medical and Dental UniversityBunkyoJapan

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