Japanese Journal of Ophthalmology

, Volume 57, Issue 1, pp 68–73

Photodynamic therapy combined with intravitreal bevacizumab and sub-tenon triamcinolone acetonide injections for age-related macular degeneration

  • Chikako Yoshizawa
  • Wataru Saito
  • Shigeki Hirose
  • Hirokuni Kitamei
  • Kousuke Noda
  • Susumu Ishida
Clinical Investigation

Abstract

Purpose

To report the results of triple therapy with photodynamic therapy (PDT) (PDT combined with intravitreal injection of bevacizumab (IVB) and sub-tenon injection of triamcinolone acetonide (STTA)) for the treatment of age-related macular degeneration (AMD) in Japanese patients.

Methods

This retrospective case series included 38 eyes of 38 patients with exudative AMD treated with PDT combined with IVB (1.25 mg) and STTA (40 mg). Retreatment was performed in the same manner with intervals of at least 3 months. All patients had been treatment naïve, with a follow-up period of 12 months. Best-corrected visual acuity (BCVA), macular retinal thickness (MRT) on optical coherence tomography, and the number of treatments were analyzed.

Results

The mean logarithm of the minimum angle of resolution BCVA in patients treated with PDT triple therapy was 0.86 ± 0.55 at baseline and 0.62 ± 0.55 at 12 months (p < 0.001). The mean MRT was 554.0 ± 202.6 μm at baseline and 205.1 ± 78.6 μm at 12 months (p < 0.001). During the 1-year follow-up, the average number of PDT triple therapy (treatments per patient) was 1.1. No complications, for example increase in intraocular pressure, cataract, or endophthalmitis, were observed.

Conclusions

In AMD patients, PDT triple therapy significantly improved visual acuity with a minimum number of treatments and a low risk of complications during the 1-year follow-up.

Keywords

Age-related macular degeneration Photodynamic therapy Bevacizumab Sub-tenon injection Triamcinolone acetonide 

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Copyright information

© Japanese Ophthalmological Society 2012

Authors and Affiliations

  • Chikako Yoshizawa
    • 1
  • Wataru Saito
    • 1
  • Shigeki Hirose
    • 1
  • Hirokuni Kitamei
    • 1
  • Kousuke Noda
    • 1
  • Susumu Ishida
    • 1
  1. 1.Department of OphthalmologyHokkaido University Graduate School of MedicineSapporoJapan

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