Japanese Journal of Ophthalmology

, Volume 56, Issue 2, pp 107–112

MUC5AC in juvenile conjunctival nevus

  • Hsin-Chiung Lin
  • Pao-Hsien Chu
  • Shih-Ming Jung
  • Meng-Ling Yang
  • David Hui-Kang Ma
Clinical Investigation

Abstract

Purpose

To evaluate the possible role of cysts with mucins and inflammatory cells in rapid-growing juvenile conjunctival nevus.

Methods

This was a case-control study at a university-based referral clinic. Seventeen conjunctival melanocytic lesions surgically excised from patients aged <20 years between 2001 and 2009 were examined by hematoxylin–eosin, periodic acid-Schiff, MUC5AC, and Alcian blue staining. The clinical signs of the affected patients and the histological findings were characterized.

Results

Eleven patients (3 girls and 8 boys; mean age 13.72 ± 3.60 years) underwent excision of a conjunctival nevus that had grown rapidly within a recent 6-month period. We found a significantly higher number of prominent cysts with mucins in the rapid-growing specimens than in the stable-growing control specimens (n = 6; 33.7 ± 19.9 vs. 0.9 ± 0.9%, P = 0.0005). However, the numbers of inflammatory cells were not statistically significantly different (42.17 ± 15.46 vs. 45.55 ± 16.31, P = 0.683).

Conclusions

The period of rapid growth of juvenile conjunctival nevus is not a malignant clinical sign. Although it might correlate with enlarged cysts lined by goblet cells associated with mucin secretions, the number of inflammatory cells remains relatively stable over time.

Keywords

Juvenile conjunctival nevus Cysts MUC5AC 

Copyright information

© Japanese Ophthalmological Society 2011

Authors and Affiliations

  • Hsin-Chiung Lin
    • 1
  • Pao-Hsien Chu
    • 2
  • Shih-Ming Jung
    • 3
  • Meng-Ling Yang
    • 1
  • David Hui-Kang Ma
    • 1
  1. 1.Department of Ophthalmology, Chang Gung Memorial HospitalChang Gung University College of MedicineKweishanTaiwan
  2. 2.Department of Cardiology, Chang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwan
  3. 3.Department of Pathology, Chang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwan

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