Japanese Journal of Ophthalmology

, Volume 55, Issue 4, pp 401–404

Negative correlation between aqueous vascular endothelial growth factor levels and axial length

  • Osamu Sawada
  • Taichiro Miyake
  • Masashi Kakinoki
  • Tomoko Sawada
  • Hajime Kawamura
  • Masahito Ohji
Clinical Investigation

DOI: 10.1007/s10384-011-0027-1

Cite this article as:
Sawada, O., Miyake, T., Kakinoki, M. et al. Jpn J Ophthalmol (2011) 55: 401. doi:10.1007/s10384-011-0027-1

Abstract

Purpose

The aim of this study was to evaluate the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the aqueous humor and axial length.

Methods

Aqueous humor samples were obtained from 60 eyes of 60 patients without ocular diseases other than cataracts. No patients with diabetes mellitus were included. The VEGF concentration in the aqueous humor was measured using an enzyme-linked immunosorbent assay.

Results

The VEGF concentrations in the aqueous humor samples ranged from 25 to 241 pg/ml [mean ± standard deviation (SD), 116.6 ± 46.7 pg/ml]. The axial lengths ranged from 20.98 to 31.95 mm (mean ± SD, 24.09 ± 2.06 mm). The VEGF concentrations in the aqueous humor samples were correlated with axial length (Pearson product moment correlation test, ρ = −0.373; P = 0.003).

Conclusions

The concentration of VEGF in the aqueous humor is negatively correlated with axial length.

Keywords

Vascular endothelial growth factor Aqueous humor Cataract Axial length 

Copyright information

© Japanese Ophthalmological Society  2011

Authors and Affiliations

  • Osamu Sawada
    • 1
  • Taichiro Miyake
    • 1
  • Masashi Kakinoki
    • 1
  • Tomoko Sawada
    • 1
  • Hajime Kawamura
    • 1
  • Masahito Ohji
    • 1
  1. 1.Department of OphthalmologyShiga University of Medical ScienceShigaJapan

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