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Japanese Journal of Ophthalmology

, Volume 55, Issue 1, pp 57–61 | Cite as

Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease

  • Yukihiro HorieEmail author
  • Wataru Saito
  • Nobuyoshi Kitaichi
  • Toshie Miura
  • Susumu Ishida
  • Shigeaki Ohno
Laboratory Investigation

Abstract

Purpose

Polymorphisms of the NACHT [neuronal apoptosis inhibitory protein (NAIP), CIITA, HET-E, TP1] and leucine-rich repeat protein 1 (NLRP1) gene are reported to be associated with susceptibility to vitiligo and several autoimmune diseases. Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder affecting melanocytes in the skin, eyes, inner ear, and meninges. In this study, genetic associations between VKH disease and single-nucleotide polymorphisms (SNPs) surrounding the NLRP1 gene were investigated.

Methods

Six SNPs (rs6502867, rs925597, rs3926687, rs2733359, rs878329, and rs4790796) near the NLRP1 gene, including noncoding regions, were sequenced by a direct method to genotype 167 Japanese patients with VKH disease and 187 healthy Japanese volunteers.

Results

None of the six SNPs in the NLRP1 region were significantly associated with disease susceptibility or the ocular, neurological, and dermatological manifestations of VKH.

Conclusions

Although skin manifestations are clinically similar between vitiligo and VKH disease, the genetic and immunological mechanisms of these two diseases may be different.

Keywords

NALP1 single-nucleotide polymorphism uveitis Vogt-Koyanagi-Harada disease 

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Copyright information

© Japanese Ophthalmological Society (JOS) 2011

Authors and Affiliations

  • Yukihiro Horie
    • 1
    • 4
    Email author
  • Wataru Saito
    • 1
  • Nobuyoshi Kitaichi
    • 2
  • Toshie Miura
    • 1
  • Susumu Ishida
    • 1
  • Shigeaki Ohno
    • 3
  1. 1.Department of OphthalmologyHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Department of OphthalmologyHealth Sciences University of HokkaidoSapporoJapan
  3. 3.Department of Ocular Inflammation and ImmunologyHokkaido University Graduate School of MedicineSapporoJapan
  4. 4.Department of OphthalmologyHokkaido University Graduate School of MedicineSapporoJapan

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