Japanese Journal of Ophthalmology

, Volume 55, Issue 1, pp 39–44

Three-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy

Clinical Investigation

DOI: 10.1007/s10384-010-0886-x

Cite this article as:
Akaza, E., Yuzawa, M. & Mori, R. Jpn J Ophthalmol (2011) 55: 39. doi:10.1007/s10384-010-0886-x



To evaluate the visual outcomes and changes in abnormal vascular networks and polypoidal lesions of polypoidal choroidal vasculopathy (PCV) 3 years after photodynamic therapy (PDT).


We studied 43 eyes of 43 patients with PCV for 3 years. Fundus appearance, fluorescein angiography (FA) and indocyanine green angiography (IA) findings, and visual acuity (VA) before the initial PDT were compared with those 3 months, 1 year, 2 years, and 3 years after treatment.


In 24 of the 43 eyes, enlargement of the abnormal vascular network continued in a manner similar to that before PDT on IA; in eight eyes, transformation into polypoidal choroidal neovascularization (CNV) with enlargement was detected; and two eyes had the appearance of classic CNV on FA. Polypoidal lesions recurred at 3 years in 33 of the 43 eyes (77%). Mean VA (logarithm of the minimum angle of resolution) of all 43 eyes decreased to below baseline at 3 years after the initial PDT. This decrease can be explained by foveal atrophy after absorption of recurrent hemorrhagic or exudative detachment.


Long-term visual outcomes were not good owing to the high frequency of recurrent polypoidal lesions, as well as enlargement and neovascular changes involving abnormal vascular networks.


indocyanine green angiography photodynamic therapy polypoidal choroidal vasculopathy visual acuity 

Copyright information

© Japanese Ophthalmological Society (JOS) 2011

Authors and Affiliations

  1. 1.Department of OphthalmologyNihon University Surugadai HospitalTokyoJapan
  2. 2.Department of OphthalmologyNihon University Surugadai HospitalTokyoJapan

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