Japanese Journal of Ophthalmology

, Volume 54, Issue 1, pp 19–23

Comparison of patients with ocular tuberculosis in the 1990s and the 2000s

  • Jun Suzuki
  • Keiko Oh-I
  • Takeshi Kezuka
  • Jun-ichi Sakai
  • Hiroshi Goto
Clinical Investigation

Abstract

Purpose

To compare clinical findings in patients with ocular tuberculosis experienced during two different decades.

Methods

Thirty-four patients with ocular tuberculosis were divided into two groups: a 1990s group (n = 18) and a 2000s group (n = 16), according to the dates of their first outpatient visit. The clinical profiles of the two groups were then compared.

Results

More cases of the 1990s group had complications involving extraocular tuberculosis than those of the 2000s group. While various ophthalmic manifestations were observed clinically in the 1990s group, all retinal periphlebitis cases presented in the 2000s group. The proportion of patients who received antituberculous treatment was higher in the 1990s group, but the proportion who received oral corticosteroid therapy did not differ between the two periods. However, more patients underwent laser photocoagulation in the 2000s group. The percentage of eyes with final visual acuity better than 20/20 increased in the 2000s group.

Conclusions

The clinical outcome of patients with ocular tuberculosis was improved in the 2000s group, which may be attributable to the increase in active use of laser photocoagulation therapy.

Keywords

clinical manifestation prognosis treatment tuberculosis uveitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dye C, Watt CJ, Bleed DM, et al. Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally. JAMA 2005;293:2790–2793.CrossRefGoogle Scholar
  2. 2.
    Ministry of Health and Welfare of Japan. Annual Statistical Report of National Health Conditions 2007. Tokyo: Japanese International Corporation of Welfare Service; 2007. p. 137–141.Google Scholar
  3. 3.
    Global tuberculosis control. WHO report 2006. Geneva: World Health Organization; 2006.Google Scholar
  4. 4.
    Yokoi H, Goto H, Sakai J, et al. Incidence of uveitis at Tokyo Medical College Hospital. Nippon Ganka Gakkai Zasshi 1995; 99:710–714.PubMedGoogle Scholar
  5. 5.
    Goto H, Mochizuki M, Yamaki K, et al. Epidemiological survey of intraocular inflammation in Japan. Jpn J Ophthalmol 2007; 51: 41–44.CrossRefPubMedGoogle Scholar
  6. 6.
    Ishihara M, Ohno S. Ocular tuberculosis [in Japanese]. Nippon Rinsho 1998;56:3157–3161.PubMedGoogle Scholar
  7. 7.
    Gupta A, Gupta V. Tubercular posterior uveitis. Int Ophthalmol Clin 2005;45:71–88.CrossRefPubMedGoogle Scholar
  8. 8.
    Morimura Y, Okada AA, Kawahara S, et al. Tuberculin skin testing in uveitis patients and treatment of presumed intraocular tuberculosis in Japan. Ophthalmology 2002;109:851–857.CrossRefPubMedGoogle Scholar
  9. 9.
    Goto H. Clinical consideration in the diagnosis and treatment of tuberculous uveitis. Folia Ophthalmol Jpn 2001;52:461–467.Google Scholar
  10. 10.
    Kotake S, Kimura K, Yoshihara K, et al. Polymerase chain reaction for the detection of Mycobacterium tuberculosis in ocular tuberculosis. Am J Ophthalmol 1994;117:805–806.PubMedGoogle Scholar
  11. 11.
    Sakai J, Matsuzawa S, Usui M, et al. New diagnostic approach for ocular tuberculosis by ELISA using the cord factor as antigen. Br J Ophthalmol 2001;85:130–133.CrossRefPubMedGoogle Scholar
  12. 12.
    Kurup SK, Buggage RR, Clarke GL, et al. Gamma interferon assay as an alternative to PPD skin testing in selected patients with granulomatous intraocular inflammatory disease. Can J Ophthalmol 2006;41:737–740.CrossRefPubMedGoogle Scholar
  13. 13.
    Varma D, Anand S, Reddy AR, et al. Tuberculosis: an underdiagnosed aetiological agent in uveitis with an effective treatment. Eye 2006;20:1068–1073.CrossRefPubMedGoogle Scholar
  14. 14.
    Kawamura M, Sueshige N, Imayoshi K, et al. Enzyme immunoassay to detect antituberculous glycolipid antigen (anti-TBGL antigen) antibodies in serum for diagnosis of tuberculosis. J Clin Lab Anal 1997;11:140–145.CrossRefPubMedGoogle Scholar
  15. 15.
    Bramante CT, Talbot EA, Rathinam SR, et al. Diagnosis of ocular tuberculosis: a role for new testing modalities? Int Ophthalmol Clin 2007;47:45–62.CrossRefPubMedGoogle Scholar
  16. 16.
    Yamamoto S, Yamamoto T. Historical Review of BCG vaccine in Japan. Jpn J Infect Dis 2007;60:331–336.PubMedGoogle Scholar
  17. 17.
    Rodrigues LC, Diwan VK, Wheeler JG. Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a metaanalysis. Int J Epidemiol 1993;22:1154–1158.CrossRefPubMedGoogle Scholar
  18. 18.
    Alvarez S, McCabe WR. Extrapulmonary tuberculosis revisited: a review of experience at Boston City and other hospitals. Medicine (Baltimore) 1984;63:25–55.Google Scholar

Copyright information

© Japanese Ophthalmological Society (JOS) 2010

Authors and Affiliations

  • Jun Suzuki
    • 1
    • 2
  • Keiko Oh-I
    • 1
  • Takeshi Kezuka
    • 1
  • Jun-ichi Sakai
    • 1
  • Hiroshi Goto
    • 1
  1. 1.Department of OphthalmologyTokyo Medical University HospitalTokyoJapan
  2. 2.Department of OphthalmologyTokyo Medical University HospitalTokyoJapan

Personalised recommendations