Japanese Journal of Ophthalmology

, Volume 53, Issue 4, pp 345–351 | Cite as

Functional imaging using the retinal function imager: Direct imaging of blood velocity, achieving fluorescein angiography-like images without any contrast agent, qualitative oximetry, and functional metabolic signals

  • David Izhaky
  • Darin A. Nelson
  • Zvia Burgansky-Eliash
  • Amiram Grinvald


The Retinal Function Imager (RFI; Optical Imaging, Rehovot, Israel) is a unique, noninvasive multiparameter functional imaging instrument that directly measures hemodynamic parameters such as retinal blood-flow velocity, oximetric state, and metabolic responses to photic activation. In addition, it allows capillary perfusion mapping without any contrast agent. These parameters of retinal function are degraded by retinal abnormalities. This review delineates the development of these parameters and demonstrates their clinical applicability for noninvasive detection of retinal function in several modalities. The results suggest multiple clinical applications for early diagnosis of retinal diseases and possible critical guidance of their treatment.

Key Words

blood flow functional intrinsic signal metabolic responses oximetry perfusion maps retinal imaging 


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Supplementary material (3.3 mb)
Movie: retinal flow in normal eye


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Copyright information

© Japanese Ophthalmological Society (JOS) 2009

Authors and Affiliations

  • David Izhaky
    • 1
  • Darin A. Nelson
    • 1
  • Zvia Burgansky-Eliash
    • 1
    • 2
  • Amiram Grinvald
    • 3
    • 4
  1. 1.Optical Imaging LtdRehovotIsrael
  2. 2.Department of OphthalmologyEdith Wolfson Medical CenterHolonIsrael
  3. 3.Department of NeurobiologyThe Weizmann Institute of ScienceRehovotIsrael
  4. 4.Department of NeurobiologyWeizmann Institute of ScienceRehovotIsrael

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