Japanese Journal of Ophthalmology

, Volume 53, Issue 4, pp 334–344 | Cite as

Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins

  • Daniel Ts’o
  • Jesse Schallek
  • Young Kwon
  • Randy Kardon
  • Michael Abramoff
  • Peter Soliz


We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina that are robust and spatially colocalized to the sites of stimulation. However, the technique is in its infancy and many questions as to the underlying mechanisms remain. In particular, the source and nature of the activity-dependent intrinsic optical signals in the retina need to be characterized and their anatomic origins determined. The studies described here begin to address these issues. The evidence indicates that the imaged signals are driven by the outer retinal layers and have a dominant hemodynamic component.

Key Words

functional retinal imaging hemodynamics intrinsic signals optical imaging 


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Copyright information

© Japanese Ophthalmological Society (JOS) 2009

Authors and Affiliations

  • Daniel Ts’o
    • 1
    • 5
  • Jesse Schallek
    • 1
  • Young Kwon
    • 2
  • Randy Kardon
    • 2
    • 3
  • Michael Abramoff
    • 2
    • 3
  • Peter Soliz
    • 4
  1. 1.Department of NeurosurgerySUNY Upstate Medical UniversitySyracuseUSA
  2. 2.Department of Ophthalmology and Visual ScienceUniversity of IowaIowa CityUSA
  3. 3.Veterans AdministrationIowa CityUSA
  4. 4.VisionQuest BiomedicalAlbuquerqueUSA
  5. 5.Department of NeurosurgerySUNY Upstate Medical UniversitySyracuseUSA

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