Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins
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We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina that are robust and spatially colocalized to the sites of stimulation. However, the technique is in its infancy and many questions as to the underlying mechanisms remain. In particular, the source and nature of the activity-dependent intrinsic optical signals in the retina need to be characterized and their anatomic origins determined. The studies described here begin to address these issues. The evidence indicates that the imaged signals are driven by the outer retinal layers and have a dominant hemodynamic component.
Key Wordsfunctional retinal imaging hemodynamics intrinsic signals optical imaging
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- 21.Okawa Y, Fujikado T, Miyoshi T, Hirohara Y, Mihashi T, Tano Y. Contribution of retinal ganglion cell activity to intrinsic signals. Invest Ophthalmol Vis Sci 2007;48:3845.Google Scholar
- 26.Schallek JB, Li H, Kardon RH, et al. Stimulus-evoked intrinsic optical signals in the retina: spatial and temporal characteristics. Invest Ophthalmol Vis Sci 2009 (in press).Google Scholar
- 27.Schallek JB, Kardon RH, Kwon YH, Abramoff MD, Soliz P, Ts’o D. Stimulus-evoked intrinsic optical signals in the retina: pharmacological dissection reveals outer retinal origins. Invest Ophthalmol Vis Sci 2009 (in press).Google Scholar