Japanese Journal of Ophthalmology

, Volume 51, Issue 6, pp 431–436

Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey

  • Nobuko Mizuki
  • Akira Meguro
  • Iwai Tohnai
  • Ahmet Gül
  • Shigeaki Ohno
  • Nobuhisa Mizuki
LABORATORY INVESTIGATION

DOI: 10.1007/s10384-007-0473-y

Cite this article as:
Mizuki, N., Meguro, A., Tohnai, I. et al. Jpn J Ophthalmol (2007) 51: 431. doi:10.1007/s10384-007-0473-y

Abstract

Purpose

Behçet's disease (BD) is known to be associated with HLA-B*51 in many different ethnic groups. Recently, the major histocompatibility complex class I chain-related gene A (MICA), located near the HLA-B gene, has been proposed as a candidate gene for BD susceptibility in several ethnic groups. To compare the relative contribution of MICA polymorphisms and HLA-B*51 to BD in different ethnic groups, we studied MICA polymorphisms in Turkish BD patients.

Methods

Thirty-three Turkish BD patients and 65 healthy controls were enrolled for analysis of polymorphisms in the extracellular domains of MICA.

Results

The phenotype frequencies of MICA*009 were significantly higher in BD patients (75.8%) than in controls (29.2%) (P = 0.000015). HLA-B*51 was also significantly more frequent in BD patients (81.8%) than in controls (29.2%) (P = 0.0000007). A strong association existed between MICA*009 and HLA-B*51. To assess the confounding effect of MICA*009 on HLA-B*51, we performed a stratification analysis that showed that BD was distinctly associated only with HLA-B*51.

Conclusion

Our results indicate that the major susceptibility gene for BD is HLA-B*51 and that the association between MICA*009 and BD arises from a strong linkage disequilibrium with HLA-B*51. However, we suggest that MICA*009 likely elicits an immune effect secondary to BD. Jpn J Ophthalmol 2007;51:431–436 © Japanese Ophthalmological Society 2007

Key words

Behçet's disease HLA-B51 MICA polymorphism Turkish Behçet's patients 

Copyright information

© Japanese Ophthalmological Society 2007

Authors and Affiliations

  • Nobuko Mizuki
    • 1
  • Akira Meguro
    • 2
  • Iwai Tohnai
    • 1
  • Ahmet Gül
    • 3
  • Shigeaki Ohno
    • 4
  • Nobuhisa Mizuki
    • 2
  1. 1.Department of Oral and Maxillofacial SurgeryYokohama City University Graduate School of MedicineYokohamaJapan
  2. 2.Department of Ophthalmology and Visual ScienceYokohama City University Graduate School of MedicineYokohamaJapan
  3. 3.Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of Ophthalmology and Visual SciencesHokkaido University Graduate School of MedicineSapporoJapan
  5. 5.Department of Ophthalmology and Visual ScienceYokohama City University Graduate School of MedicineYokohamaJapan

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